نتایج جستجو برای: farber disease
تعداد نتایج: 1490893 فیلتر نتایج به سال:
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.
Half a century ago, a diagnosis of leukemia in a child was considered a death sentence. Today, approximately 85% of children diagnosed with this once fatal disease are cured. The discovery that ushered in this dramatically transformed outlook was the observation by Sidney Farber (1903–1973) and his colleagues in Boston in 1948 that drugs that acted against the vitamin folic acid could produce r...
1 Van Vooren JP, Turneer M, Yernault JC, Dc Bruyn J, Burton E, Legros F, Farber CM. A multidot finmunobinding assay for the serodiagnosis oftuberculosis. Comparison with ELISA technique. J Immunol Methods 1988; 113:45-49 2 Van %boren JP, Farber CM, Motte 5, De Bruyn J, Legros F, Yernault JC. Assay of specific antibody response to myobacterial antigen for the diagnosis of a pleural effusion in a...
1 Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, 2 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 3 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA and 4 Department of Genetics, Harvard Medical School, Boston, MA, USA * Corresponding author. Center for Cancer System...
1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; 2Institute of Cancer, Barts and the London School of Medicine, London, United Kingdom; 3Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY; 4Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY; 5Department of P...
Granulomatous lesions affecting the reticuloendothelial system produce a group of disorders having certain striking clinical features. The condition known as Hand-Schuller-Christian disease is one of this group, and the well-known SchiillerChristian triad of exophthalmos, diabetes insipidus, and multiple lesions in the skull was for many years considered to be pathognomonic. More recently Otani...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید