road traffic accidents (rta) are one of the most important causes of death and disability all over the world. in developing countries the problem is more complicated. based on the estimation by unicef, rate of rta in iran is 20 times more than world’s average. in iran among all unintentional fatal injuries inflicted on children under five, traffic related fatalities are the leading cause of dea...

background: motor vehicle traffic injuries are indeed one of the most important worldwide health problems. opioids can induce a depressant effect on the central nervous system which may increase the risk of traffic accidents. this cross-sectional case-control study was conducted in marvdasht, iran to investigate the presence of drugs in hospitalized non-fatally injured drivers of motor vehicles...

background elimination of suicide attempts is impossible, but they can be reduced dramatically by an organized planning. the present study aimed to survey the suicide trends in fars province (iran), during 2004-2009 to better understand the prevalence and status of suicide.   methods this survey was a cross-sectional study. the demographic data were collected from the civil status registry betw...

Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic and huge burden to healthcare systems worldwide. One of the characteristic symptoms COVID-19 is asymptomatic hypoxemia, also called happy hypoxia, silent or hypoxemia. Patients with hypoxemia often have no subjective symptoms, such as dyspnea, even though judged objectiv...

BACKGROUND Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an important regulator of nitric oxide synthase enzymatic function. METHODS AND RESULTS In the hph-1 mouse w...

A histological review of dura mater taken from a post-mortem series of 50 paediatric cases aged up to 5 months revealed fresh bleeding in the dura in 36/50, the bleeding ranging from small perivascular haemorrhages to extensive haemorrhage which had ruptured onto the surface of the dura. Severe hypoxia had been documented clinically in 27 of the 36 cases (75%). In a similar review of three infa...

objectives the main aim of this study was to assess the road emergency sites (recs) in iran. materials and methods provincial data were used for this purpose. concentration index, concentration curve, lorenz curve, and the gini coefficient were calculated to assess the distribution of recs. results the results of this study showed that the distribution of recs was in favor of provinces with hig...

Objective(s): The aim of this study is to explore the potential role of hypoxia/reoxygenation in necroptosis in cultured rat renal tubular epithelial cell line NRK-52E, and further to investigate its possible mechanisms.Materials and Methods: Cells were cultured under different hypoxia-reoxygenation conditions                        in vitro. MTT assay was used to measure the cell proliferation...

Objective(s): The present study was aimed to investigate the influence of thoracic epidural blockade on hypoxia-induced pulmonary hypertension in rats. Materials and Methods: Forty eight Wistar rats were randomly divided into 4 equal groups, named normoxia hypoxia hypoxia/ ropivacaine and hypoxia/saline. Animals were placed in a hypoxia chamber and instrumented with epidural catheters at the t...