While it is generally accepted that most B lymphocytes express Fe-receptors (FcR) (1), 1 evidence for the expression of FcR by T cells is controversial. Thus, while some works have claimed that a high proportion of thymus cells display FcR (2), others have failed to demonstrate FcR on these cells (1). FcR, however, could be detected on several murine T cell lymphomas (2, 3, and footnote 2), and...

Although fludarabine, cyclophosphamide, and rituximab (FCR) together are established as a standard first-line treatment of younger patients with chronic lymphocytic leukemia (CLL), there is little information to guide the management of patients with CLL refractory to, or who have relapsed after, receiving frontline FCR treatment. To define optimal salvage strategy and identify patients unsuitab...

Thymus cells of murine fetuses at day 12 of gestation are exclusively of the CD3-CD4-CD8-CD44+CD25- phenotype, which is known as a hallmark of the most immature subset of thymus cells. In the present study, we show that day 12 fetal thymus (FT) cells express Fc gamma RII/ III (FcR) at a broad range of levels on their surface. The FcR+ FT cells seem to represent T lineage cells, because a large ...

Feed conversion efficiency is a measure of how well an animal converts feed into live weight and it is typically expressed as feed conversion ratio (FCR). FCR and related traits like growth rate (e.g. days to 110 kg-D110) are of high interest for animal breeders, farmers and society due to implications on animal performance, feeding costs and environmental sustainability. The objective of this ...

Identification of bacteria associated with desirable productivity outcomes in animals may offer a direct approach to the identification of probiotic bacteria for use in animal production. We performed three controlled chicken trials (n = 96) to investigate caecal microbiota differences between the best and poorest performing birds using four performance measures; feed conversion ratio (FCR), ut...

OBJECTIVE The feed intake (FI) and feed efficiency are economically important traits in ducks. To obtain insight into this economically important trait, we designed an experiment based on the residual feed intake (RFI) and feed conversion ratio (FCR) of a random population Pekin duck. METHODS Two thousand and twenty pedigreed random population Pekin ducks were established from 90 males mated ...

In a dose-response study, dietary levels of standardized ileal digestible methionine (dMet), lysine (dLys), and threonine (dThr) were optimized by response surface methodology (RSM) using a central composite rotatable design in starting broiler chicks that were feed-deprived 2 d posthatch. In total, 60 floor pens of 6 birds each were assigned to 15 diets of central composite rotatable design co...

Two polymorphic forms of Fc receptor III (FcR III) are expressed on human neutrophils. These differ with respect to their apparent molecular masses after digestion with N-glycanase, and with respect to their reactivity with MAb Gran 11 and alloantisera which recognize determinants (NA1 and NA2) of the biallelic neutrophil antigen (NA) system. To determine the molecular basis for this polymorphi...

Direct immunization with amyloid protein (A ) and passive transfer of anti-A antibodies reduce A accumulation and attenuate cognitive deficits in transgenic models of Alzheimer’s disease (AD). The reduction in A deposition has been proposed to involve microglial phagocytosis of A immune complexes via Fc receptors (FcRs). We have examined the efficacy of A immunization in amyloid precursor prote...

A virally encoded, high-affinity Fc receptor (FcR) is found on herpes simplex virus type 1 (HSV-1) particles and infected cells where its binding of non-immune IgG protects cells from host-mediated lysis. Whilst mutation or aglycosylation of the IgG CH2 domain reduced binding to human FcR, the interaction with HSV-1 FcR was not affected. However, the HSV-1 FcR, unlike human FcR, discriminates b...