Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis an increased risk to develop diseases later in life. However, as a single cause this development cannot be investigated. Here, ...

Bisphenol A [BPA, 2,2-bis(4-hydroxyphenyl)propane], a xenoestrogen, is a monomer for the synthesis of polycarbonate plastics, epoxy resins, and composites. Metabolism of BPA to the monoglucuronide will determine the extent of its estrogenicity in vivo. Investigation of the metabolism of BPA (500 microM) by isolated female rat hepatocytes confirmed the formation of BPA glucuronide as the major m...

BACKGROUND Monosodium glutamate (MSG) is a commonly used food additive and there is growing concern that this may play a critical role in the aethiopathogenesis of anovulatory infertility. OBJECTIVES The effect of monosodium glutamate (MSG) used as food additive on the ovaries of adult Wistar rat was investigated. METHODS Adult female Wistar rats (n=24) weighing between 182 to 186grams were...

The role of dopamine in the rewarding aspects of sexual behaviour in female rats was investigated. This is a unique model because sexual behaviour is only rewarding when copulatory stimuli are experienced at the preferred rate of copulation for a female rat. In addition, increases in dopamine in the nucleus accumbens occur during sexual behaviour only when the female achieves this preferred rat...

Role of sex differences on oxidative stress induced by benzene has been studied in liver, kidney and lungs of rat. It was observed that benzene administration enhanced lipid peroxidation in liver, kidney and lungs of rat, nevertheless, significant variations were recorded in male and female rats. Decrease of GSH and CYTP(450)2E1 was higher in female rats than male rats except lungs. The results...

PURPOSE Differential display analysis was used to look for gender differences in lacrimal gland gene expression. The expression of a female-specific mouse lacrimal gland mRNA that encoded pancreatic lipase-related protein 1 (PLRP1) was identified and characterized. METHODS Differential display analysis of the exorbital lacrimal glands of male and female Swiss Webster mice detected a potential...

Glutathione (GSH) conjugation of trichloroethylene (Tri) to form S-(1,2-dichlorovinyl)glutathione (DCVG) has been implicated in the nephrotoxicity and nephrocarcinogenicity of Tri. Marked sex- and species-dependent differences exist, however, in the susceptibility to Tri-induced renal toxicity, with the male rat being the most susceptible. The present study, therefore, focuses on potential diff...