entaNYL transdermal patches (Duragesic and other generic brands) are a mainstay in the treatment of Fchronic pain, yet the US health care community and patients alike continue to face challenges regarding the safe use of this product. Despite numerous warnings from drug manufacturers, patient safety groups, and even the Food and Drug Administration (FDA), the Institute for Safe Medication Pract...

Objective There are no strong guidelines on how long or how we should undertake conservative treatment during the acute period of an osteoporotic vertebral compression fracture (VCF). Methods We treated 202 patients with conservative treatment on VCF from March 2012 to August 2015. On inclusion criteria, 75 patients (22 males and 53 females) were included in the final analysis. After admissio...

Transdermal administration of morphine and fentanyl using a pluronic lecithin organogel was evaluated in dogs. IV administration of morphine and fentanyl resulted in therapeutic serum drug concentrations. Following transdermal administration, however, median serum drug concentrations were never above the limit of quantitation for morphine or fentanyl. These findings indicate that use ofa pluron...

Previous studies have demonstrated that Δ-tetrahydrocannabinol (THC) enhances the antinociceptive potency of many opioids administered by a variety of different routes of administration. We hypothesized that THC would enhance fentanyl or buprenorphine analgesia via the transdermal route of administration. THC was first demonstrated to enhance opioid antinociception when both drugs were administ...

Fentanyl is used for pain treatment during pregnancy in human beings and animals. However, fentanyl pharmacokinetics during pregnancy has not been fully established. The aim of this study was to characterize fentanyl pharmacokinetics in pregnant sheep after intravenous and transdermal dosing during surgical procedure performed to ewe and foetus. Pharmacokinetic parameters reported for non-pregn...

Postoperative management of pain has traditionally utilized intravenous (IV) morphine for pain control. An alternative approach to the invasive patient-controlled analgesia (PCA) system is the administration of transdermal analgesics, such as fentanyl. In 2006 the Food and Drug Administration (FDA) approved the fentanyl hydrochloride (fentanyl HCl) iontophoretic transdermal system (ITS), which ...

The aim of this study was to evaluate the influence of CYP3A5 and ABCB1 gene polymorphisms on fentanyl pharmacokinetics and clinical responses in cancer patients undergoing conversion to a transdermal system. Sixty Japanese cancer patients being treated with a fentanyl transdermal reservoir system according to the current Japanese guidelines were enrolled. Blood samples were obtained 192 h afte...

Due to the high prevalence of opioid prescription following orthopedic procedures, there is a growing need establish an animal model system evaluate effects opioids on bone remodeling. Rabbits have been employed as organisms in research they exhibit well-defined cortical remodeling similar humans. Existing rabbits has limited modes administration that are short-acting and require repeated appli...