alcohol directly affects astroglial cell function, including inflammation-related activity.  and it also affects microglial cell development and function in specific ways that interfere with microglial interactions with the immune system and with neurons. neuroinflammatory processes might be involved in alcohol-induced brain damage. alcohol use, misuse and getting used to it causes different ki...

potent induction of fetal hemoglobin (hbf) production results in alleviating the complications of β-thalassemia and sickle cell disease (scd). hbf inducer agents can trigger several molecular signaling pathways critical for erythropoiesis. janus kinase/signal transducer and activator of transcription (jak/stat), mitogen activated protein kinas (mapk) and phosphoinositide 3-kinase (pi3k) are con...

our previous studies on thalassemia patients, homozygous or compound heterozygous for severe beta thalassemia mutations, has suggested that 5’hs4-lcr and/or xmn1-hbg2 backgrounds, which were linked in our thalassemia patients, are important in determining the blood transfusion dependency of these individuals. while the majority of patients with aa/-- 5’hs4/xmn1 background, were severely depende...

background several factors may cause infertility and fetal loss. blood groups antigens seem to be implied in the mechanisms of infertility and fetal loss. maternal natural antibody can react against father’s blood group antigens on spermatozoa. the effects of parental blood group system on infertility and fetal surveillance perceived by its manifestation in prezygotic (caused infertility) and p...

isolation of cell free fetal dna (cffdna) from maternal serum usually leads to very low concentrations of dna impeding further resolving through conventional methods of electrophoresis. although several protocols have been described for capillary electrophoresis (ce) of double stranded dna, they usually need using special polymers or coated capillaries which degrade over time. herein, we propos...

a true estimation of gestational age (ga) plays an important role in quality maternity care and scheduling the labor date. this study aimed to evaluate the normal fetal kidney length (kl) and its correlation with ga. a cross-sectional study on 92 pregnant women between 8th and 10th week of gestation with normal singleton pregnancy underwent standard ultrasound fetal biometry and kidney length m...

hepatic dysfunction is a frequent manifestation in patients with sickle cell anemia. it is usually a multifactorial process. a rare benign form of extreme hyperbilirubinemia, presumably due to intrahepatic sickling, may be the cause. we report a 9 year old girl with sickle-thalassemia hemoglo binopathy, presenting with profound jaundice. sickle cell disease is often mild in the iranian populati...

objective: this study was performed for evaluation of accuracy of fetal weight estimation by clinical & ultrasonographic methods in iranian population . meterial & method:this prospective study was conducted on two hundred preg .nant mothers that reffered to obstetric department during years 1378 & 1379 . findings:our study showed that there was statistically significant difference between clin...

background: although the pathogenesis of diabetes type 1 (t1d) is not fully elucidated. different clusters of lymphocytes such as cd4+ and cd8+ t cells are involved in it. moreover, the mechanism of how stem-cell therapy results in significant therapeutic outcomes in diabetes remains obscure. in the current study, we aimed to analyze lymphocyte subsets in patients with t1d before and after trea...

background: efficient induction of fetal hemoglobin (hbf) is considered as an effective therapeutic approach in beta thalassemia. hbf inducer agents can induce the expression of γ-globin gene and produce high levels of hbf via different epigenetic and molecular mechanisms. thalidomide and sodium butyrate are known as hbf inducer drugs. material and methods : cd133 + stem cells were isolated fro...