The influence of maternal hypothyroxinemia on the expression of the glucose transporters, GLUT1 and GLUT3, in rat fetal brain and placenta was investigated. Fetal growth was retarded in hypothyroxinemic pregnancies, but only before the onset of fetal thyroid hormone synthesis. Placental weights were normal, but placental total protein concentration was reduced at 19 days gestation (dg). Immunob...

Front cover: Cover image: Distribution of HOPX and BLBP in cerebellum brain stem from a 21 wpc human fetal brain. is most prevalent corpus pontobulbare (CPB). seem to occupy different regions this cellular aggregate dominated by strong immunoreactivity. also scattered the present dentate nucleus as well blood vessel walls. In cerebellar cortex mostly confi ned Purkinje cell layer. Also note rea...

Background: Toxoplasma gondii is a significant cause of abortion in sheep and goats in the world. Toxoplasmosis is caused reproduction disorders such as fetal resorption, early embryonic death, mummification, abortion, stillbirth, neonatal and fetal death in sheep . Objectives: The aim of this study was to detect T. gondii infection in ovine aborted fetuses in Khorasan Razavi province. Methods:...

BACKGROUND Assessment of the fetal brain volume and blood flow is important in the evaluation of fetal growth. We used three-dimensional (3D) ultrasound and power Doppler to assess the fetal brain volume and the blood flow index during normal gestation. The relationships of these parameters were further analyzed. METHODS We assessed the total volume and the blood flow index of the fetal brain...

BACKGROUND Fetal hypoxia has been implicated in the abnormal brain development seen in newborns with congenital heart disease (CHD). New magnetic resonance imaging technology now offers the potential to investigate the relationship between fetal hemodynamics and brain dysmaturation. METHODS AND RESULTS We measured fetal brain size, oxygen saturation, and blood flow in the major vessels of the...

OBJECTIVE The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR). STUDY DESIGN In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by ...

Most children with in utero alcohol exposure do not exhibit all features of fetal alcohol syndrome (FAS), and a challenge for clinicians is to make an early diagnosis of fetal alcohol spectrum disorders (FASD) to avoid lost opportunities for care. In brain, correct neurodevelopment requires proper angiogenesis. Since alcohol alters brain angiogenesis and the placenta is a major source of angiog...

background: silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. the goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on balb/c mice fet...

Epigenetic processes play a key role in orchestrating transcriptional regulation during development. The importance of DNA methylation in fetal brain development is highlighted by the dynamic expression of de novo DNA methyltransferases during the perinatal period and neurodevelopmental deficits associated with mutations in the methyl-CpG binding protein 2 (MECP2) gene. However, our knowledge a...

Objective During labor the fetal head is subjected to pressure related to uterine contractions and maternal pushing. Here we systematically review what is known about fetal head compression and its effects on fetal intracranial pressure, oxygenation, blood flow and cerebral function, and the plausibility that it might cause isolated fetal brain injury. Study Design Systematic review of intrapar...