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background: in most cancer cases, the treatment choice for a pregnant patient is radiotherapy. in these patients, the abdomen is usually not exposed therefore fetus exposure is due to peripheral dose (pd). the purpose of this study was to estimate the fetal dose (the maximum pd in each pregnancy stage) for modalities available and to fabricate and evaluate a generally applicable fetal shield. m...

Mice carrying two mutant genes at the f locus on chromosome 1 3 have severe anemia during fetal development, characterized by hypochromic and microcytic red blood cells laden with many iron granules. Ultrastructural studies reveal that the cxcessive nonheme iron accumulated in mutant ( f/f ) fetal erythrocytes is present within mitochondria, similar to those seen in human sideroblastic anemia. ...

Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...

Maternal exercise during pregnancy has been shown to improve the long-term health of offspring in later life. Mitochondria are important organelles for maintaining adequate heart function, and mitochondrial dysfunction is linked to cardiovascular disease. However, the effects of maternal exercise during pregnancy on mitochondrial biogenesis in hearts are not well understood. Thus, the purpose o...

An increase in oxygen tension at birth is one of the key signals that initiate pulmonary vasodilation in the fetal lung. We investigated the hypothesis that targeting endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane regulates reactive oxygen species (ROS) formation in the fetal pulmonary artery endothelial cells (PAEC) during this transition. We isolated PAEC and pul...

aim : the aim of this study was to evaluate and compare three available methods for mitochondrial isolation from a human cell line to predict the best method for each probable application.   background : organelle isolation is gaining importance in experimental laboratory settings. mitochondrial dysfunction may affect tumorgenesis process. there are some evidences that transplantation of health...

In the course of studies on protein synthesis by unidentified subcellular particle in the mitochonmitochondria isolated from fetal calves liver, we drial fraction . Because these ribosomes incorporate found active' 80 S ribosomes associated with an leucine-'H under conditions that label only intramitochondrial ribosomes in adult mammalian sys1 Active under incubation conditions that support tem...