Fexofenadine (Allegra® 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was confirmed by a prick test, oral provocation test, and flow cytometry assisted-...

Fexofenadine is the hydrochloride salt of terfenadine’s active metabolite. In 2006, the FDA approved an oral suspension for the management of chronic idiopathic urticaria and seasonal allergic rhinitis in children. This review article summarizes the clinical pharmacology, therapeutic applications, drug-drug interactions, adverse events and food-drug interactions of fexofenadine that have been r...

P-glycoprotein (P-gp), encoded by the multidrug resistance 1 gene (MDR1/ABCB1), exhibits very broad substrate specificity and plays important roles in drug disposition. The purpose of the present study was to examine the effect of impaired P-gp activity on the plasma pharmacokinetics of P-gp substrates in collies with or without homozygous mutant alleles producing truncated P-gp. Three therapeu...

BACKGROUND Sedating antihistamines may impair driving performance as seriously as alcohol. OBJECTIVE To compare the effects of fexofenadine, diphenhydramine, alcohol, and placebo on driving performance. DESIGN Randomized, double-blind, double-dummy, four-treatment, four-period crossover trial. SETTING The Iowa Driving Simulator. PARTICIPANTS 40 licensed drivers with seasonal allergic rh...

Objectives: This study was undertaken to compare the efficacy and safety of fexofenadine with chlorpheniramine and betamethasone in allergic rhinitis. Methods: This was a prospective observational study on 75 patients of allergic rhinitis. They were randomly divided into 3 groups of 25 patients each for receiving fexofenadine, chlorpheniramine and betamethasone respectively. Improvement of symp...

Fexofenadine is a selective, nonsedating H(1)-receptor antagonist approved for symptoms of allergic conditions, which is mainly excreted into feces via biliary excretion. The purpose of this study is to investigate its pharmacokinetics in mice and rats to determine the role of P-glycoprotein (P-gp) in its biliary excretion. In mice, biliary excretion clearance (17 ml/min/kg) accounted for almos...

Effects of olopatadine hydrochloride, a histamine H(1) receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fex...

Objective: The objective of this study was to investigate the influence Decalepis hamiltonii (D. hamiltonii), a traditional plant used in herbal medicine, on intestinal absorption and pharmacokinetics fexofenadine, substrate P-glycoprotein (P-gp), rats. Methods: In situ perfusion tests were conducted assess permeability fexofenadine. P-gp ATPase activity also evaluated understand modulatory eff...

BACKGROUND This is the first prospective, randomized, double-blind, placebo-controlled study showing statistical improvement of an H(1)-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period. OBJECTIVE This randomized, placebo-controlled, parallel-group, double-blind study was performed to assess the efficacy and safety of fexofenadine...