BACKGROUND The effect of fibroids that do not distort the endometrial cavity on pregnancy rate (PR) and implantation rate (IR) is controversial. Use of oocyte donor-derived embryos offers an ideal patient population to study the effect of fibroids in patients utilizing assisted reproductive technologies (ARTs). METHODS We conducted a retrospective cohort study of patients undergoing oocyte do...

background: The influence of fibroids on fertility is poorly understood. Submucosal and intramural fibroids that distort the endometrial cavity have been associated with decreased pregnancy rates (PRs) following IVF treatment. However, there is uncertainty about the effect of intramural fibroids that do not distort the endometrial cavity on IVF outcomes. methods: We conducted a systematic revie...

African American (black) women have a higher rate, larger size and worse morbidity of uterine leiomyomata (fibroids) than white women. The racial difference in gene expression may contribute to the high burden of fibroids in black women. Dysregulated miRNAs have been found to be significantly related to tumorigenesis of fibroids, but racial difference of miRNA expression in fibroids and matched...

Objectives. The study was to assess the level of knowledge of, perception of, and attitude towards uterine fibroids among women diagnosed with the condition. Methods. It is a cross-sectional descriptive study carried out among women diagnosed as having uterine fibroids in two gynaecological clinics in Lagos, Nigeria. Eligible women were recruited and a structured interviewer-administered questi...

Uterine fibroids are benign solid tumors that are present in the majority of women. While often asymptomatic, fibroids can result in abnormal uterine bleeding, pelvic pressure, pain, subfertility, dyspareunia and other symptoms. Submucous and intramural fibroids are most associated with heavy menstrual bleeding; subserosal fibroids are more often innocuous unless sufficiently large so as to con...

Fibroid is the commonest benign neoplasm of the uterus in females, composed of smooth muscle with variable amount of fibrous connective tissue, hence named as leiomyoma or fibromyoma. It is the commonest of all pelvic tumours in females, excluding pregnancy; being more common in nulliparous. It can be intra uterine / extra uterine. Extrauterine fibroids though do occur, but are not as common as...

OBJECTIVE To provide recommendations regarding the best management of fibroids in couples who present with infertility. Usual and novel treatment options for fibroids will be reviewed with emphasis on their applicability in women who wish to conceive. OPTIONS Management of fibroids in women wishing to conceive first involves documentation of the presence of the fibroid and determination of li...

Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract, occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains poorly understood. A role for atypically activated mammalian target of rapamycin (mTOR) pathway in the pathogenesis of uterine fibroids has been suggested in several studies. We identified that G protein-coupled receptor...

BACKGROUND The impact of fibroids, not encroaching the endometrial cavity, have on the rate of success of IVF is still controversial. Recent meta-analyses suggest a detrimental effect of intramural lesions but not subserosal lesions. However, they also emphasize the need for further evidence. In order to elucidate this, we designed a prospective cohort study to compare the rate of success of IV...

BACKGROUND Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids. OBJECTIVE...