BACKGROUND Immortal cell lines and cell lines derived from operative specimens transplanted into animal models are used in meningioma research. We address 2 criticisms of the mouse xenograft flank tumor model: Why are tumor induction rates derived from operative specimens low and inconsistent? Are flank tumors meningiomas? METHODS Meningioma cell cultures were processed for Giemsa-band karyot...

Saw palmetto supplements (SPS) are commonly consumed by men with prostate cancer. We investigated whether SPS fatty acids and phytosterols concentrations determine their growth-inhibitory action in androgen-sensitive LNCaP cells and hamster flank organs. High long-chain fatty acids-low phytosterols (HLLP) SPS ≥ 750 nM with testosterone significantly increased and ≥500 nM with dihydrotestosteron...

In this analysis, an attempt has been made to study the effects of included angle, hardness, rake angle, tool approach angle and nose radius of cutting inserts on flank wear with the surface roughness as constraint. The selected parameters are varied through three levels. A new parametric study without considering any kind of benchmark problems in this area is performed and methodology has been...

Little is known at the present time about the molecular basis and mechanisms of morphogenesis. The present study is an attempt to determine what influence the extracellular matrix has on the initial outgrowth of the limb bud. Stage -12 to -18 chick embryo lateral plates were examined in relation to proline and sulfate incorporation into collagen and proteoglycan. The flank and limbs incorporate...

In this paper, predictive modeling of cutting and ploughing forces, stress distributions on tool faces and temperature distributions in the presence of tool flank wear are presented. The analytical and thermal modeling of orthogonal cutting that is introduced in Karpat, Zeren and Özel [3] extended for worn tool case in order to study the effect of flank wear on the predictions. Work material co...

Vernier acuity and jump detection were investigated using a perturbation technique, in which a flanking line is placed to one side of the target line. The size and direction of vernier displacement, or jump, required for no apparent change of location is strongly influenced by the separation between the flanking line and the test line and by its polarity. For flanks within a zone extending appr...

The relationship between rift zones and flank instability in ocean island volcanoes is often inferred but rarely documented. Our field data, aerial image analysis, and Ar/Ar chronology from Anaga basaltic shield volcano on Tenerife, Canary Islands, support a rift zone— flank instability relationship. A single rift zone dominated the early stage of the Anaga edifice (~6–4.5 Ma). Destabilization ...