The Development and Assessment of a Herbal Floating Tablet for Peptic Ulcer Disease. goal creating herbal floating tablet is to extend the drugs duration in gastrointestinal tract. This will increase bioavailability result greater absorption than with convectional dose form. Due its gastro-retentive feature, medicine remains at site inflammation longer amount time, resulting more targeted actio...

Lamivudine, a BCS Class I synthetic nucleoside analogue, has a a short biological half-life of 5–7 and is mainly absorbed in the upper gastrointestinal tract. The purpose of the study is to develop a controlled release floating tablets of lamivudine employing HPMC K4M and sodium alginate. The floating tablets of lamivudine were prepared employing HPMC K4M and sodium alginate as matrix formers a...

BACKGROUND AND THE PURPOSE OF THE STUDY Baclofen, a centrally acting skeletal muscle relaxant, is indicated in the long-term treatment of spasticity. It is difficult to formulate baclofen sustained release dosage forms because its absorption on arrival to colon (or even before) is low or nonexistent. In the present investigation efforts were made to improve the bioavailability of baclofen by in...

Objective: The recent study's objective was to optimize and formulate a controlled-release gastro-retentive floating tablet of RG using central composite design, which provides continuous release Repaglinide for up 24 h. Methods: (RG-GRF Tablet) prepared by direct compression method. optimization carried out three-factor three-level Central Composite design. amount Eudragit RSPO (A), HPMC K-100...

The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of bisoprolol. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with g...

Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...

Migraine follows circadian rhythm in which headache is more painful at the awakening time. This needs administration of dosage form at night time to release drug after lag period when pain gets worse. Sumatriptan succinate is a drug of choice for migraine. Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life. Present work deals with application of design of ex...