The past few decades have witnessed significant advances in the development of functionalized metal/metal oxide nanoparticles including those of inorganic noble metals and magnetic materials stabilized by various polymeric ligands. Recent applications of such functionalized nanoparticles, including those in bio-imaging, sensing, catalysis, drug delivery, and other biomedical applications have t...

Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe. Two N-propynyl analogs of the major anthranilic diamide insecticides chlorantraniliprole (Chlo) and cyantraniliprole (Cyan) were accordingly s...

A new dissymmetric bis(thiosemicarbazone) ligand, H2L2, containing a 4-(1-naphthyl)-3-thiosemicarbazone branch has been easily prepared and characterized. The reactivity of this ligand the hybrid isopropylthiosemicarbazone/naphtoylhydrazone, H2L1, with zinc(II), copper(II) nickel(II) nitrates in presence different amounts lithium hydroxide explored. results show that although both ligands prese...

The regional and cellular localization of the two subtypes of dopamine receptors, D1 and D2, have been ascertained in rat forebrain by use of fluorescent dopaminergic antagonist ligands. (R,S)-5-(4'-aminophenyl)-8-chloro-2,3,4,5-tetrahydro-3- methyl-[1H]-3-benzazepin-7-ol, the 4'-amino derivative of the high-affinity D1-specific antagonist SCH 23390, and the D2 selective antagonist N-(p-aminoph...

Abstract Precisely changing the optical properties of gold nanoclusters (AuNCs) with different ligands offers a promising prospect for highly sensitive and selective drug sensing. In this study, AuNCs were synthesized d -tryptophan ( -Trp) its derivatives as ligands. Optical measurements showed that -Trp@AuNCs produced higher fluorescence intensity shorter emission wavelength than -Trp-derivati...

The dynamics of agonist-stimulated opioid receptor internalization and trafficking have been difficult to study in living cells in part because the available probes were inadequate. To overcome this obstacle, six new fluorescent opioid peptides were developed. Dermorphin (DERM), deltorphin (DELT), TIPP, and endomorphin were conjugated to BODIPY TR or Alexa Fluor 488, two fluorescent dyes with d...

An isopyrazole (4H-pyrazole)-embedded nonane-2,4,6,8-tetraone derivative was synthesized as a masked-tetraketone for stepwise and multiple functionalization. The has six possible tautomers, but exists predominantly 12π-electron conjugated keto-enamine-imine-enol form, which also observed in the solid state by single crystal X-ray analysis. Stepwise functionalization to introduce metal-coordinat...