Simulating serial-target antibacterial drug synergies using flux balance analysis 4 5 6 7 8 9 10 11 Andrew S. Krueger¶, Christian Munck ¶, Gautam Dantas, 12 George M. Church, James Galagan, Joseph Lehár, Morten O.A. Sommer 13 14 1 Boston University, 44 Cummington St, Boston, MA, USA. 15 2 Technical University of Denmark, Novo Nordisk Foundation Center for Biosustainability, Hørsholm, 16 Denmark...

Summary: FBA-SimVis is a VANTED plug-in for the constraintbased analysis of metabolic models with special focus on the visual exploration of metabolic flux data resulting from model analysis. The program provides a user-friendly environment for model reconstruction, constraint-based model analysis, and interactive visualisation of the simulation results. With the ability to quantitatively analy...

MOTIVATION Although constraint-based flux analysis of knockout strains has facilitated the production of desirable metabolites in microbes, current screening methods have placed a limitation on the number knockouts that can be simultaneously analyzed. RESULTS Here, we propose a novel screening method named FastPros. In this method, the potential of a given reaction knockout for production of ...

For over two decades, Flux Balance Analysis (FBA) has been successfully used for predicting growth rates and intracellular reaction in microbiological metabolism. An aspect that is often omitted from this analysis, segregation or heterogeneity between different cells. In work, we propose an extended FBA method to model cell size distributions balanced conditions. Hereto, a mathematical descript...