this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

Strict measure on the need to control microbial contamination in the formulation of solid dosage forms such as tablets and capsules are not usually in place as is done in other pharmaceutical preparations. The presence of microorganisms in some common excipients such as starch and lactose powders, and distilled water used in tablet formulation was investigated in this study. Organisms isolated ...

Adulteration in pharmaceutical products is common all over the world particularly oraldosage forms like tablets, gelatin capsules. According to previous studies there were many techniquesare available recognize counterfeit medicines. Near Infrared Spectroscopic techniques widely usedin this area due its numerous advantages. In work, we used ASD Field Spec4 Spectroradiometerhaving broad spectral...

Tablet is most popular among all dosage forms today because of its convenience, ease administration, greater flexibility in form design, production, and low cost non-invasive therapy. Formulation tablets requires API along with excipients. Excipients include lubricants, diluents, binders, glidants, disintegrants, sweetening agents, flavoring etc. Recent trends indicate that multi-particulate dr...

The development of age appropriate formulations for the paediatric population has become one key areas focus pharmaceutical industry - with a subsequent influence on excipient use. Selection excipients safety and tolerability is major hurdle in formulation development. Various factors selection excipients, including target group, route administration dosage form. Evaluation these clear rational...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

Considerable research efforts have been directed towards understanding the enigma of P-glycoprotein (P-gp) in drug development and delivery. P-gp is a multi-specific drug efflux transporter that plays a significant role in governing the bioavailability of various anti-cancer drugs. Modulation of this efflux transporter by various traditional 'chemosensitisers' forms a distinctive approach in im...

■ ■ 92% reduction in solvent usage and sample injected in t ro du C t io n Compendial methods are often used in the analysis of generic drugs. Typically, methods are developed and submitted based on a specific formulation. However when the excipients are changed, the method specified in a USP monograph may be inadequate in eluting all components off of the column. The result can be deterioratin...

The low bioavailability (15%) and good solubility of Domperidone Maleate in acidic pH following oral administration favours development of a gastro retentive formulation. Gastroretentive floating matrix tablets of Domperidone Maleate were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M. From the Preformulation studies for drug excipients compatibility it ...

In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orodispersible tablets by using croscarmelloe sodiu...