BACKGROUND Numerous studies have recently been conducted to investigate genetic mechanisms in cancer causes and pathogenesis. Some of these studies have shown that there were certain specific chromosomal defects in normal cells of cancer patients and in their first-degree relatives. It was suggested that these individuals were susceptible to cancer development when compared with people without ...

The paper deals with the synthesis of a non-fragile state controller with reduced design complexity for a class of continuous-time nonlinear delayed symmetric composite systems. Additive controller gain perturbations are considered. Both subsystems and interconnections include time-delays. A low-order control design system is first constructed. Then, stabilizing controllers with norm bounded ga...

The fragile X mental retardation protein (FMRP) plays a role in the control of local protein synthesis in the dendrites. Loss of its production in fragile X syndrome is associated with transcriptional dysregulation of the gene. Recent work demonstrates that Sp1 and NRF1 transcriptionally control this gene. Other studies reveal how the microRNA pathway and signaling are related to FMRP function ...

The paper is concerned with robust H∞ non-fragile controller design for uncertain descriptor systems with time-delay. A descriptor system has potential to describe a wide class of physical systems. It can give a representation of the system with algebraic constraints. A unique characteristic of descriptor systems is possible impulse modes and nonregularity, which do not appear in state-space sy...

In various studies of sporadic breast cancers, 40-70% were strongly positive for fragile histidine triad (Fhit) protein expression, whereas only 18% of BRCA2 mutant breast cancers demonstrated strong Fhit expression, suggesting that the BRCA2 repair function may be necessary to retain intact fragile common chromosome fragile site 3B(FRA3B)/FHITloci. In the current study, 22 breast tumors with d...

Fragile X syndrome, the most common form of hereditary mental retardation, causes disruption in the development of dendrites and synapses, the targets for axonal growth in the central nervous system. This disruption could potentially affect the development, wiring, and targeting of axons. The current study utilized diffusion tensor imaging (DTI) to investigate whether white matter tract integri...

When multiple robots collaboratively transport or manipulate a load, both motion and force need to be considered. This is especially true when the load is fragile or needs to be moved rapidly. Tight force coordination is possible if all robots share their force information and the grasp geometry is completely known. When this is not the case, a common approach is to use the leader/follower stra...

Males with fragile X syndrome (FXS) have difficulties with social interaction and many show autistic features. This study examined whether the social deficits characteristic of FXS are associated with theory of mind difficulties. Two groups of boys with FXS participated: a group with few autistic features and a group with many autistic features. An intellectual disability control group also par...

Attention problems are among the most impairing features associated with fragile X syndrome (FXS). However, few studies have examined behavioral development of inhibitory control in very young children with FXS. We examined attentional control in 3-6 year boys with FXS using both an experimental inhibitory control paradigm and parent-report of attention problems. Study 1 examined attentional co...