A study of the diffusion of parabens from topical formulations is presented here. In particular, four different topical formulations, namely, a water-in-oil emulsion, an oil-in-water emulsion, and two hydrophilic gels (Pemulen gel and Carbopol gel) were produced, containing a mixture of three common parabens, namely, methylparaben (MP), ethylparaben (EP), and propylparaben (PP). An analytical m...

Arabica coffee (Coffea arabica L.) kintamani is a superior agricultural product from Bali. contains many compounds, one of which caffeine beneficial for health and beauty. This study aims to formulate beans into gel dosage form. The optimization formula bean was made using the D-Optimal method combination HPMC propylene glycol as observation variables spreadability, pH, viscosity preparation ex...

of ill vitro release testing as a QA tool to ensure batch-to-batch uniformity has been gaining both increasing popularity and contempt in the pharmaceutical industry. Regardless of views and opinions, it is worthwhile to be prepared to conduct such studies if necessary. Currently, the most publicized methods use horizontal ("Franz or Modified Franz") diffusion cells, with an artificial support ...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

Cellulite was identified by the orange-peel appearance of skin surface that presents in 80-90% post-pubertal women. Caffeine and grape seed oil were known can be used as an anti-cellulite agent. Microemulsion systems are could enhance diffusion rate drugs through skin. This study conducted to develop a microemulsion gel containing caffeine determine effect caffeine's vitro profile. prepared usi...

All Australian species previously placed in Horaeomorphus Schaufuss are revised. None of them was found to belong to this predominantly Oriental genus. Four new genera are established to accommodate these species: Leascydmus gen. n. for Scydmaenus simplicicornis Lea; Scydmaenozila gen. n. for Phagonophana macrosticta Lea (type species) and Phagonophana latipennis Lea; Spinosciacharis gen. n. fo...

Benign prostatic hyperplasia (BPH) is the most common condition in aging men, associated with lower urinary tract symptoms. It is caused due to the augmented levels of the androgen dihydrotestosterone. Dutasteride, a 5α-Reductase inhibitor has been recommended for the treatment of BPH upon oral administration. However, long term oral administration of dutasteride may cause sexual problem in man...

BACKGROUND The aim of this study was to investigate the intestinal mucus-penetrating properties and intestinal cellular uptake of two types of liposomes modified by Pluronic F127 (PF127). METHODS The two types of liposomes, ie, PF127-inlaid liposomes and PF127-adsorbed liposomes, were prepared by a thin-film hydration method followed by extrusion, in which coumarin 6 was loaded as a fluoresce...

The photorefractive properties of semi-insulating AlGaAs-GaAs multiple quantum wells are described for the transverse Franz-Keldysh geometry with the electric field in the plane of the quantum wells. Combining the strong electroabsorption of quantum-confined excitons with the high resistivity of semi-insulating quantum wells yields large nonlinear optical sensitivities. The photorefractive quan...