Peptide modification has emerged as an important topic in the academic community and pharmaceutical industry. However, they are primarily focused on diversification of amines, thiols, alcohols. Direct chemoselective acid residues peptides is relatively underdeveloped. In this context, we report a novel efficient method for direct functionalization peptides. By using ynamides reaction partners, ...

Article history: Available online 17 July 2008

3 Proof of Theorem 1 9 3.1 Estimation of the g1 term. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.2 Estimation of the g3 term. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 3.3 Estimation of the g2 term. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 3.4 Putting everything together. . . . . . . . . . . . . . . . . . . . . ....