OBJECTIVE To study the endogenous sex hormone levels in natural postmenopausal women and their association with the presence of internal carotid artery (ICA) atherosclerosis. DESIGN Case-control study METHODS We compared 56 patients with severe ICA atherosclerosis referred for carotid artery endarterectomy (CEA) with 56 age-matched control subjects free of severe atherosclerotic disease. Th...

OBJECTIVE A potential risk of testosterone replacement therapy is an increase in the incidence of prostate cancer, but it is unclear whether higher levels of serum testosterone are associated with a higher risk of prostate cancer. We prospectively evaluated serum androgen concentrations and prostate cancer risk. METHOD Included were 794 members of the Baltimore Longitudinal Study of Aging. We...

CONTEXT Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity. OBJECTIVE To determine whether the association between serum testosterone concentration and mood in older men is independent of physical comorbidity. DESIGN Cross-sectional study. SE...

ObjectiveTo evaluate the effect of testosterone treatment on metabolic and inflammation parameters leukocyte-endothelium interactions in transgender men (TGM).DesignProspective observational study.SettingUniversity hospital.Patient(s)One hundred fifty-seven TGM.Intervention(s)Administration undecanoate (1,000 mg, intramuscular) every 12 weeks.Main Outcome Measure(s)Endocrine parameters, adhesio...

Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) hospitalized patients which linked to a worse prognosis. However, these were conducted with active and long-term consequences are still not yet known. Therefore, we aimed evaluate the late impact of COVID-19 pneumonia on testosterone recovered, post-hospitalized males. Methods: We enrolled 55 pneumo...

INTRODUCTION Obesity is associated with reduced testosterone and worsened erectile and sexual function in men. Weight loss improves these outcomes. High protein diets potentially offer anthropometric and metabolic benefits, but their effects on reproductive and sexual outcomes is not known. AIM To examine the long-term effects of weight loss with a higher protein or carbohydrate diet on testo...

OBJECTIVE To evaluate the incidence of hypogonadism in men with metabolic syndrome and its correlation with serum insulin levels. METHODS Observational, transversal study with 80 men with metabolic syndrome. The individuals were divided into two groups: Group 1: 56 patients (70%) with total testosterone > 300 ng/dL (normal gonadal function); Group 2: 24 patients (30%) with total testosterone ...

The effect of smoking on androgen levels is important given the recent interest in the link between low levels of androgens and the development of cardiovascular disease. Numerous studies examining the effects of cigarette smoking on the levels of total and free testosterone have reported conflicting findings, but there has been no accurate assessment of the effects of cigarette smoking on the ...

In order to describe the relationships between endogenous sex hormones and bone mineral density in healthy postmenopausal women, we carried out a cross-sectional study of 90 community-based women, all at least one year since their last menstrual period (mean 9.6 +/- 4.9 years, range 1-22) and with a serum oestradiol level less than 100 pmol/l. None was currently using hormone replacement therap...

STUDIES over the last decade have shown that the male hormone, testosterone, declines with age in men (1,2). This decline is associated with a decrease in libido, muscle mass and strength, leptin levels, bone mineral density (BMD), hematocrit, and cognition (3–6). It also has been recognized that total testosterone is a poor measurement of gonadal status because of the increase in sex hormone b...