pemphigus vulgaris (pv) is one of the most common and studied autoimmune disorders of skin. the knock down of desmogleins in the skin by igg antibodies will eventually leads to mucocutaneous problems in both genders. targeting the cardinal molecules involved in the pathways of immune response is the main goal of given therapy. with regard to the side effects of long term use of immunosuppressiv...

leishmaniasis is one of the major health problems and categorized as a class i disease (emerging and uncontrolled) by world health organization (who), causing highly significant morbidity and mortality. indeed, more than 350 million individuals are at risk of leishmania infection, and about 1.6 million new cases occur causing more than 50 thousands death annually. because of the severe toxicity...

OBJECTIVE Shark type II collagen (SCII) is extracted as a glycoprotein from the cartilage of blue shark (Prionace glauca). We aim to confirm the effects of oral tolerance of SCII on inflammatory and immune responses to the ankle joint of rheumatoid-arthritis rats induced by Complete Freund's Adjuvant (CFA). MATERIALS AND METHODS The onset of rheumatoid arthritis (RA) was observed 14 ± x days ...

This review collects information on sources of skin sensitisation data and computational tools for the estimation of skin sensitisation potential, such as expert systems and (quantitative) structure-activity relationship (QSAR) models. The review also captures current thinking of what constitutes an integrated testing strategy (ITS) for this endpoint. The emphasis of the review is on the useful...

Tato případovĂĄ studie přibliĹžuje dramatickĂŠ ĹživotnĂ­ osudy sourozencĹŻ Gerty (Gertrudy) a Harryho (Heřmana) FreundovĂ˝ch v kontextu mezivĂĄlečnĂŠho komunistickĂŠho hnutĂ­. Narodili se v roce 1908 (Harry) 1909 (Gerta) do praĹžskĂŠ středostavovskĂŠ, nĂĄrodnostně smĂ­ĹĄenĂŠ rodiny (s německou, Ĺžidovskou českou identitou) oba byli pod vlivem matky Terezie FreundovĂŠ (1885–1982...

New potent vaccine adjuvants are desirable for increasing the efficacy of novel vaccine modalities such as DNA and peptides. We therefore tested if syngeneic erythrocytes could serve as delivery vectors for selected HIV peptides and compared the potency of these constructs to immunization with peptides in phosphate buffered saline or in incomplete Freunds adjuvant. Immunization of mice with pep...

Abstract Der 1983 gegründete „Deutschlandrat“ stellt in der Geschichte Bundesrepublik einen bedeutendsten Versuche Neuen Rechten dar, sich zu organisieren und eine gemeinsame Gesprächsplattform bilden. Ihm gehörten unter anderem Armin Mohler, Hellmut Diwald Franz Schönhuber an, die große Hoffnung das Vorhaben setzten. Aufsatz wirft Blick hinter Kulissen dieses Projekts ordnet es Bonner Republik...

abstract background and aims: vaccination of poultry has a major impact on the prevention and control of avian influenza viruses. nanobiotechnology techniques provide a new approach for improvement of influenza vaccine efficacy. in this study, efficacy of an inactivated nano-adjuvant vaccine developed based on an endemic h9n2 virus was evaluated in spf chickens. materials and methods: in each t...

objective: the effects of natural adjuvants were examined on total and differential wbc counts in lung lavage of sensitized guinea pigs. materials and methods: in three sensitized groups of guinea pigs including: untreated sensitized animals (s), sensitized animals treated with adjuvant g2 (s+g2) and g2f (s+g2f) as well as non-sensitized group (c) (n=6 for each group), total and differential wb...

objective: to report a case of long-term disease free and successful pregnancy after fertility sparing staging surgery with adjuvant chemotherapy in a 46,xy gonadal dysgenetic with malignant germ cell tumor. materials and methods: a case report from a university hospital about a 19-year-old female with 46,xy karyotype ( swyer syndrome). the patient underwent bilateral gonadectomy and staging wi...