The technical performance of serum fructosamine assay as a short-term index of diabetic control was evaluated by using the BM/Hitachi 747-200 Automatic Analyzer (Boehringer Mannheim Corp). Intra- and interassay precisions (CV) were <2%. Linearity was confirmed up to 1000 micromol/L. Lipemia, produced artificially or from hypertriglyceridemia in vivo, did not interfere with measurement of serum ...

Serum fructosamine and glycated haemoglobin (HbA1) were measured in capillary samples from diabetic children and compared with samples from non-diabetic children. Glycaemic control was assessed clinically and by average daily glucose values recorded by home monitoring. Fructosamine correlated with HbA1 and with average glucose values measured over 30 days. HbA1 also correlated with average gluc...

OBJECTIVE Discordance between HbA(1c) and fructosamine estimations in the assessment of glycemia is often encountered. A number of mechanisms might explain such discordance, but whether it is consistent is uncertain. This study aims to coanalyze paired glycosylated hemoglobin (HbA(1c))-fructosamine estimations by using fructosamine to determine a predicted HbA(1c), to calculate a glycation gap ...

PURPOSE Glycosylated hemoglobin (HbA1c) is often used as an indicator of glucose control. It usually reflects the average glucose levels over two to three months, and is correlated with the development of long-term diabetic complications. However, it can vary in cases of hemoglobinopathy or an altered red blood cell lifespan. The serum fructosamine levels reflect the mean glucose levels over tw...

OBJECTIVE The glycation gap (the difference between measured A1C and the value predicted by regression on fructosamine) is stable and is associated with microvascular complications of diabetes but has not hitherto been estimated within a clinically useful time frame. We investigated whether two determinations 30 days apart suffice for a reasonably reliable estimate if both A1C and fructosamine ...

The mean fructosamine concentration in plasma of diabetics (n = 200) differed significantly (p less than 0.001) from those of a hospitalized nondiabetic population (n = 163)--the latter mean being essentially the same for ambulatory subjects (n = 145), expectant mothers (n = 58), and patients with renal failure (n = 31), regardless of sex. In the diabetic group, values for plasma fructosamine c...

Some suggest that measurements of plasma fructosamine concentration should be corrected for the plasma protein (or albumin) concentration because the extent of glycation per volume depends on both protein and glucose concentrations. Several reports, however, demonstrate a poor correlation between plasma fructosamine and albumin concentrations in diabetic patients. In vitro kinetic and in vivo s...

BACKGROUND Hemoglobin A1c (HbA1c) is the standard measure to monitor glucose control in diabetes mellitus and is a marker of future cardiovascular risk. Fructosamine and glycated albumin are markers of short-term glycemic control, but their associations with cardiovascular outcomes are uncharacterized. METHODS AND RESULTS We measured glycated albumin and fructosamine in 11 104 participants wi...

Background: Glycation is the process of non enzymatic addition or insertion of sugar to proteins, DNA and lipids. Fructosamine is the generic name for plasma proteins ketoamines; it refers to structure of ketoamine rearrangement product formed by interaction of fructose with ε-amino group of lysine residues of albumin. Its determination monitors the short term glycemic changes and may have a ro...

of fructosamine values between these two populations are not significantly different. These results imply two different distributions for measurements of Hb A1 but the same gaussian (anamorphosis) distribution for measurements of fructosamine. H,qerglycemk patients. Statistical analysis of the data (Mann-Whitney test) shows a significant difference of fructosamine averages between normal subjec...