The main aim of our presentation is to consider in a real Hilbert space H the following controllability problem (P )  ẏ(t) ∈ A(t)y(t) + F (t, yt) +Bu(t), for t ∈ J := [0, T ], T > 0, t 6= tk, k = 1, . . . , p, y(t) = φ(t), t ∈ I := [−τ, 0], τ > 0, y(tk ) = y(tk), y(t + k ) = y(tk) + Ik(ytk), k = 1, . . . , p, where F : J ×PC(I,H) ( H is a multivalued mapping with convex and compact values, ...

Arabinoxylan (AX) is a major dietary fibre component found in a variety of cereals. Numerous health benefits of arabinoxylans have been reported to be associated with their solubility and molecular features. The current study reports the development of a functional bread using a combination of AX-enriched material (AEM) and optimal commercial endoxylanase. The total AX content of bread was incr...

BACKGROUND Bacterial inclusion bodies (IBs) are non-toxic protein aggregates commonly produced in recombinant bacteria. They are formed by a mixture of highly stable amyloid-like fibrils and releasable protein species with a significant extent of secondary structure, and are often functional. As nano structured materials, they are gaining biomedical interest because of the combination of submic...

A Cauchy problem for a functional-differential inclusion of neutral type with a nonconvex right-hand side is investigated. Questions of the solvability of such a problem are considered, estimates analogous to the Filippov’s estimates are obtained and the density principle is proved. 2000 Mathematics Subject Classification: 34A60, 34G20, 34K35, 49J30, 49K25.

Cytochrome c oxidase (COX)-deficient fibers and multiple mitochondrial DNA (mtDNA) deletions are frequent findings in sporadic inclusion body myositis (s-IBM). However, the functional impact of these defects is not known. We investigated oxygen desaturation during exercise using the forearm exercise test, accumulation of lactate during exercise using a cycle ergometry test and mitochondrial cha...

Bacterial inclusion bodies, while showing intriguing amyloid-like features, such as a beta-sheet-based intermolecular organization, binding to amyloid-tropic dyes, and origin in a sequence-selective deposition process, hold an important amount of native-like secondary structure and significant amounts of functional polypeptides. The aggregation mechanics supporting the occurrence of both misfol...

BACKGROUND For a long time IBs were considered to be inactive deposits of accumulated target proteins. In our previous studies, we discovered IBs containing a high percentage of correctly folded protein that can be extracted under non-denaturing conditions in biologically active form without applying any renaturation steps. In order to widen the concept of correctly folded protein inside IBs, G...