Targeting induced local lesions in genomes (TILLING) is a reverse-genetic method for identifying point mutations in chemically mutagenized populations. For functional genomics, it is ideal to have a stable collection of heavily mutagenized lines that can be screened over an extended period of time. However, long-term storage is impractical for Drosophila, so mutant strains must be maintained by...

Large numbers of protein expression changes are usually observed in mouse models for neurodegenerative diseases, even when only a single gene was mutated in each case. To study the effect of gene dose alterations on the cellular proteome, we carried out a proteomic investigation on murine embryonic stem cells that either overexpressed individual genes or displayed aneuploidy over a genomic regi...

Cloud computing is one of the concept in virtual technology. Virtualization means that is not real but its provides the all facilities to all different users. Virtualization provides efficient solution in different number of real time applications. Cloud computing is ready to provide the services efficiently to all users. Different numbers of users are submitting the different jobs. All jobs ar...

By investigating flow level characteristics of Internet traffic, we are able to trace the root of load imbalance in hash-based load-splitting schemes. We model flow popularity distributions as Zipf-like and prove that under typical Internet traffic mix, a hash scheme cannot balance workload statistically, not even in the long run. We then develop a novel load-balancing packet scheduler for para...

Today, cloud computing applications are rapidly constructed by services belonging to different cloud providers and service owners. This work presents the inter-cloud elasticity framework, which focuses on cloud load balancing based on dynamic virtual machine reconfiguration when variations on load or on user requests volume are observed. We design a dynamic reconfiguration system, called inter-...

Cloud scale load balancers, such as Ananta and Duet are critical components of the data center (DC) infrastructure, and are vital to the performance of the hosted online services. In this paper, using traffic traces from a production DC, we show that prior load balancer designs incur substantial overhead in the DC network bandwidth usage, due to the intrinsic nature of traffic redirection. More...

Balancer chromosomes are multiply inverted chromosomes that suppress meiotic crossing over and prevent the recovery of crossover products. Balancers are commonly used in Drosophila melanogaster to maintain deleterious alleles and in stock construction. They exist for all three major chromosomes, yet the molecular location of the breakpoints and the exact nature of many of the mutations carried ...

Counting networks were proposed by Aspnes, Herlihy and Shavit 4] as a technique for solving multiprocessor coordination problems. We describe a method for tolerating an arbitrary number of faults in counting networks. In our fault model, the following errors can occur dynamically in the counting network data structure: 1) a balancer's state is spuriously altered, 2) a balancer's state can no lo...