نتایج جستجو برای: g1896a
تعداد نتایج: 73 فیلتر نتایج به سال:
BACKGROUND Hepatitis B virus (HBV) is one of the most common human pathogens that cause aggressive hepatitis and advanced liver disease (AdLD), including liver cirrhosis and Hepatocellular Carcinoma. The persistence of active HBV replication and liver damage after the loss of hepatitis B e antigen (HBeAg) has been frequently associated with mutations in the pre-core (pre-C) and core promoter (C...
BACKGROUND In this study, we evaluated the prevalence of the most common mutations occurring in Enhancer II (EnhII), Basal Core Promoter (BCP), Precore (PC), and Core (C) regions of hepatitis B virus (HBV) genome. OBJECTIVES We also investigated the correlation between HBV variants, their genotypes, and patients' HBe antigen (HBeAg: soluble shape of the capsid antigen) status. PATIENTS AND ...
Previously we reported that the exposure to hepatitis B virus (HBV) infection serves as a major threat among the treatment naive HIV infected population of eastern India. Hence, molecular characterization of these strains is of utmost importance in order to identify clinically significant HBV mutations. A total of 85 treatment naive HIV/HBV co-infected participants were included of whom the com...
BACKGROUND Genetic polymorphisms of pri-miR-34b/c and pre-miR-196a2 have been reported to be associated with the susceptibility to cancers. However, the effect of these polymorphisms and their interactions with hepatitis B virus (HBV) mutations on the development of hepatocellular carcinoma (HCC) remains largely unknown. We hypothesized that these polymorphisms might interact with the HBV mutat...
Stop codon mutation on Pre-Core, G1896A, was found in 23 of 98 patients (23.47%); among them, 20 of 23 (86.96%) are genotype B. Mutations related to antiviral drug resistance with frequency more than 1% in the reverse transcriptase (RT) domain of Polymerase gene were identified. 83.67% sequences have more than one mutation. 50% sequences have mutation at rtI169V/M, and all belong to sub-genotyp...
Stop codon mutation on Pre-Core, G1896A, was found in 23 of 98 patients (23.47%); among them, 20 of 23 (86.96%) are genotype B. Mutations related to antiviral drug resistance with frequency more than 1% in the reverse transcriptase (RT) domain of Polymerase gene were identified. 83.67% sequences have more than one mutation. 50% sequences have mutation at rtI169V/M, and all belong to sub-genotyp...
BACKGROUND We recently reported complex hepatitis B virus (HBV) drug resistant and concomitant vaccine escape hepatitis B surface antigen (HBsAg) variants during human immunodeficiency virus (HIV) co-infection and antiretroviral therapy (ART) exposure in Ethiopia. As a continuation of this report using the HBV positive sera from the same study participants, the current study further analyzed th...
Hepatitis B virus (HBV) has a high mutation rate and exists as a mixture of genetically different but closely related variants. We present a HBV DNA co-transfection fitness assay and use it to evaluate the relative fitness of different HBV variants in two scenarios: seroconversion process and occupation of an ecological niche. In the seroconversion experiment, subgenotype D1 (sgtD1) deletion (1...
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