A monoclonal antibody, RA4, was developed that recognizes retinal ganglion cell axons in the mature retina. Between embryonic days 3 and 9, the RA4 antigen was associated with cell bodies in certain regions of the retina in addition to the ganglion cell axons. The RA4-positive cells were of 3 types: an apolar cell adjacent to the ventricular surface, a bipolar cell that spanned the thickness of...

An antibody against recoverin, the calcium-binding protein, labels photoreceptors, cone bipolar cells, and a subpopulation of cells in the ganglion cell layer. In the present study, we sought to establish the origin and identity of the cells expressing recoverin in the ganglion cell layer of the rat retina. By double labeling with rhodopsin, we demonstrate that early in development some of the ...

We report that the most common retinal ganglion cell type that remains after optic nerve transection is the M1 melanopsin ganglion cell. M1 ganglion cells are members of the intrinsically photosensitive retinal ganglion cell population that mediates non-image-forming vision, comprising ∼2.5% of all ganglion cells in the rat retina. In the present study, M1 ganglion cells comprised 1.7±1%, 28±14...

Purpose: Evaluation of ganglion cell complex measurement and the use parameters lamina cribrosa depth in early diagnosis progression patients with suspected glaucoma.
 Materials Methods: Measurements were taken Heidelberg Spectralis Spectral Domain Optical Coherence Tomography from both groups. Ganglion thicknesses measured segmentation analysis. Lamina depths by using optic nerve head ima...

Optical coherence tomography (OCT) is considered a key research tool to monitor neurodegenerative processes in CNS disorders. This particularly applicable multiple sclerosis (MS), which retinal changes (peripapillary nerve fiber layer and ganglion cell–inner plexiform [GCIPL] thicknesses) tend reflect MRI markers of damage atrophy, especially eyes not affected by previous optic neuritis.1

The electrosensory lobe (ELL) of mormyrid electric fish is the first stage in the central processing of sensory input from electroreceptors. The responses of cells in ELL to electrosensory input are strongly affected by corollary discharge signals associated with the motor command that drives the electric organ discharge (EOD). This study used intracellular recording and staining to describe th...