Last month’s US FDA and WHO approval of CervarixTM, GlaxoSmithKline’s (GSK [London, UK]) vaccine against human papillomavirus (HPV) types 16 and 18 [101], boosted GSK’s position in the global HPV vaccine market. Gardasil, Merck’s vaccine against HPV types 6, 11, 16 and 18, obtained US FDA and WHO approvals in 2006. US FDA rejection of Cervarix 2 years ago, together with Cervarix’s lack of prote...

We report the case of a 19-year-old woman who received a complete vaccine program by Gardasil. After one year, Greiner HPV test revealed HPV51 positivity. This case report highlights the limits of the vaccine, and the need to have a clinical follow up of patients despite the vaccination program.

KEY CLINICAL MESSAGE A woman diagnosed with a recurrent vulval carcinoma after initial treatment with radiochemotherapy is presented. After three additional relapses she was vaccinated with Gardasil. She has had no relapses in her vulvar area for 39 months and an overall progression-free survival of almost 24 months.

conclusions the results of this meta-analysis showed that gardasil and cervarix vaccines are highly effective against cervical cancer. according to the point that approximately 50% of cervical cancers and human carcinogenicity are related to hpv-16 infection, the bivalent hpv vaccine might have protective effects against hpv-16 cin2-3 lesion and cervical cancer. results by combining the results...

Pre-adolescent girls (9-15years) have the option of receiving a two dose HPV vaccine series at either a six month or one year interval to provide protection from HPV 16, the most prevalent type associated with cervical cancers, as well as several other less prevalent types. This series of vaccinations is highly likely to protect her from HPV infection until she enters the routine screening prog...

There are solid research data to support the construction of a quadrivalent (HPV6, 11, 16 and 18) L1 VLP vaccine. Accordingly, the two HR-HPV types (16 and 18) cover around 70% of all CCs, 50–70% of high-grade CIN lesions, 70% of other HPV-related genital cancers, and some 25% of low-grade CIN lesions. Similarly, in males, 70% of all anal cancers are caused by HPV16 and HPV18, as are 70% of all...

People typically attribute more responsibility to those individuals who are infected with sexually transmitted diseases (STD) than other diseases. This study tested how different routes (i.e., sexually transmitted or foodborne) of transmission have an impact on individuals' general perception on stigma/shame and the attributions of responsibility, when controlling for symptoms/conditions of the...