CONTEXT The prevalence of obesity has been increasing in modern society. Roux-en-y gastric bypass is a bariatric surgery that involves the exclusion of significant part of the stomach. Atrophy, intestinal metaplasia and gastric cancer have been associated with infection by Helicobacter pylori. OBJECTIVES To evaluate the presence of endoscopy findings and histological changes in morbid obese p...

BACKGROUND Infection with a virulent Helicobacter pylori strain is associated with gastric mucosal damage and the increased risk of gastric cancer. AIMS To examine the characteristics of host gastric mucosal responses in patients with gastric cancer, histological grade of gastritis, gastric epithelial apoptosis, and proliferation were studied. METHODS Thirty two patients with early gastric ...

BACKGROUND AND STUDY AIMS The relationship between endoscopic atrophy classification (EAC) and histological gastric atrophy and intestinal metaplasia (IM) was examined before and after Helicobacter pylori (H. pylori) eradication in order to evaluate the usefulness of EAC for detecting the risk of gastric cancer following eradication. PATIENTS AND METHODS A total of 230 patients (137 males, 93...

BACKGROUND Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers the possibility to detect preneoplastic gastric mucosal conditions. Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia. METHODS Histologica...

The loss of gastric oxyntic glands (corpus atrophy) is emerging as a marker of gastric cancer risk as indicated by low Pepsinogen I (PGI) levels 1 2. There is a need to take into account the natural history and temporal dynamics of such an entity in order to better understand its significance and especially its implications for cancer prevention and screening. Atrophy of the gastric corpus was ...

BACKGROUND AND AIM Histamine plays important physiological roles in upper gastrointestinal tract and acts via the H2 receptor. A polymorphism -1018 G>A (rs2067474) was identified in an enhancer element of the HRH2 promoter. We attempted to clarify the associations of this polymorphism with the progression of gastric mucosal atrophy. METHODS Gastric mucosa samples were obtained from 398 subjec...

The gastric cancer risk varies based on the etiology and severity of gastritis, which depends a history Helicobacter pylori infection secretory capacity stomach. Type A gastritis is associated with reverse atrophy corpus type B progressive extending from antrum to corpus. Diffuse or spotty redness in together high serum pepsinogen (PG) II levels low PG I/II ratio are observed patients H. when s...

AIMS To determine the prevalence of Helicobacter pylori in five main nationality groups with gastric ulcer, duodenal ulcer, and non-ulcer dyspepsia; and to determine the histopathological types of gastritis and assess the graded variables of Helicobacter associated gastritis. METHODS Gastric antral and corpus biopsy specimens from 437 patients were examined for the prevalence of H pylori, 337...

Eradication of Helicobacter pylori causes improvement of gastric atrophy and intestinal metaplasia. Gastric acid secretion levels in corpus predominant gastritis increase after eradication. These changes can increase the risk of reflux esophagitis and low-dosage aspirin ulcers. Although eradication may reduce the overall risk of gastric cancer, a certain degree of risk remains, related to the e...

OBJECTIVES Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). MATERIALS AND METHODS Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group r...