IQGAP1 is recognized as a negative regulator of cell-cell adhesion at adherens junctions in several cell types, including gastric mucosal cells. The histopathologic appearance of diffuse gastric carcinoma is defined by non- or poorly cohesive tumor cells, indicating abnormal intercellular adhesion. Hence, we screened 38 gastric cancers for activating point mutations in IQGAP1. In 2 of the 33 di...

Objective: Genetic factors have been the subject of many studies in cancer etiology. One most striking these is relationship between blood groups and cancer. Therefore, our study, we examined stomach, colorectal, breast, thyroid pancreatic cancers, which are common general surgery practice, with single-center data. Method: We retrospectively analyzed cases who applied to University Hospital 200...

Krukenbergtumors are ovarian metastases from non-gynecological, mainly gastrointestinal cancers, such as gastric and colorectal cancers. They very rare with a stillpoorlyelucidatedetio-pathogenesis(1). Previousretrospectivestudies have suggestedthatKrukenbergtumors associatedwithapoor prognosis compared to metastaticdiseaseatother sites resultingfrom the sameprimarydisease(2).We report here obs...

Gastric signet ring cell carcinoma (GSRCC) is an important histological type of gastric cancer. Its biological and clinical particularities distinguish it from other cancers in ways that require tailored management decision-making. This short review provides overview what known about this prevalent entity, highlights recent developments the research surrounding GSRCC, covers microbiome, immunol...

Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastr...

Lysyl oxidase (LOX) and HRAS-like suppressor (HRASLS) are silenced in human gastric cancers and are reported to have growth-suppressive activities in ras-transformed mouse/rat fibroblasts. Here, we analyzed whether or not LOX and HRASLS are tumor suppressor genes in human gastric cancers. Loss of heterozygosity and promoter methylation of LOX were detected in 33% (9 of 27) and 27% (26 of 96) of...

Lysyl oxidase (LOX) and HRAS-like suppressor (HRASLS) are silenced in human gastric cancers and are reported to have growth-suppressive activities in ras-transformed mouse/rat fibroblasts. Here, we analyzed whether or not LOX and HRASLS are tumor suppressor genes in human gastric cancers. Loss of heterozygosity and promoter methylation of LOX were detected in 33% (9 of 27) and 27% (26 of 96) of...