In this review, we analyze the effects of systemic lupus erythematosus and scleroderma on the gastrointestinal tract. There is a wide variation of gastrointestinal manifestations from these autoimmune disorders including but not limited to: oral ulcers, dysphagia, gastroesophageal refl ux disease, abdominal pain, constipation, diarrhea, fecal incontinence, pseudo-obstruction, perforation and ga...