نتایج جستجو برای: gdc
تعداد نتایج: 840 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Treatment of ruptured aneurysms with Guglielmi detachable coils (GDCs) has been shown to prevent repeat bleeding. To assess whether GDC coiling alters aneurysmal pressure, we measured intraaneurysmal pressure in two canine types of carotid artery aneurysms before and after GDC placement. METHODS A 0.014-inch guidewire with a pressure transducer was inserted into parent ...
Angiopoietin-like protein 2 (ANGPTL2) plays an important role in inflammatory carcinogenesis and tumor metastasis. The compound GDC-0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity. However, the interaction between ANGPTL2 and GDC-0152 has not been studied. It has been proven that ANGPTL2 promotes metastasis of osteosarcoma. The...
Factors determining the pharmacokinetics of 2-chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide (GDC-0449) were investigated using preclinical studies and physiologically based pharmacokinetic (PBPK) modeling. Multiple-dose studies where dogs were given twice-daily oral doses of either 7.5 or 25 mg/kg GDC-0449 showed less than dose-proportional increases in exposure on day...
A redox cycle between Ce4+ and Ce3+ is the elementary step in water gas shift (WGS) mechanism. Facilitating a +4 +3 of cerium enhanced formation oxygen vacancy which considered as dominate factor for developing WGS performance stability ceria material. Therefore, this work, we have tried to facilitate CeO 2 enrich activity. The reaction was carried out on Ni catalyst supported by Gd-doped (GDC)...
Trastuzumab, an anti-ErbB2 humanized antibody, brings benefit to patients with ErbB2-amplified metastatic breast cancers. However, the resistance to trastuzumab is common. Our previously reported H2-18, an anti-ErbB2 antibody, potently induced programmed cell death in trastuzumab-resistant breast cancer cells. Here, we aim to investigate the antitumor efficacy of H2-18 in combination with the p...
The establishment of docetaxel-based chemotherapeutic treatments has improved the survival of castration-resistant prostate cancer (CRPC) patients. However, most patients develop resistance supporting the development of therapy. The current study was undertaken to establish the therapeutic benefit to target hedgehog signaling cascade using GDC-0449 to improve the efficacy of chemotherapeutic dr...
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC-0449 initially regressed tumors, but this individual ultimately relapsed with a D473H resistance mutation in Smoothened (SMO)...
We report the usefulness of Guglielmi detachable coil (GDC) embolization by direct carotid puncture for anterior circulation aneurysms. For all 27 patients, GDC embolization by direct carotid puncture was safely performed by using a 5F sheath introducer 5 cm long and a Tracker-38 catheter. Neurologic deficits and hemorrhage were not found in any patient during the follow-up period. If the trans...
In this work, the electrocatalytic properties of novel cathodes prepared by infiltration NdBa 0.9 Co 2 O 5+ ? (NBC) into porous Gd doped Ceria (GDC) scaffolds are investigated, and comparison is provided with La 0.6 Sr 0.4 0.2 Fe 0.8 3? (LSCF) infiltrated GDC cathodes. For both formulations, symmetric cells fabricated blade coating aqueous nitrate precursor solutions until reaching 25% w/w load...
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