The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...

This study investigated the influence of a papain-based gel (Papacárie) for chemo-mechanical caries removal on bond strength to dentin. Human molars were assigned to the following groups: Group 1: sound teeth were flattened to expose dentin; Group 2: after flattening of surfaces, the papain-based gel was applied on the sound dentin; Group 3: overlying enamel from carious teeth was removed and m...

Mixed surimi gels with 5 and 8% of pea flour (PF) 1.41% protein isolate (PPI) were made to replace part the myofibrillar proteins legume compounds. Viscoelastic properties in linear viscoelastic range fresh mixed control gel compared frozen-stored for one year. Fresh PPI-surimi more flexible (higher γmax), greater energy stability E parameter) strength G′ G″ moduli) than gel. These sustained af...

CONTEXT Soft-tissue injuries are commonly treated with ice or menthol gels. Few studies have compared the effects of these treatments on blood flow and muscle strength. OBJECTIVE To compare blood flow and muscle strength in the forearm after an application of ice or menthol gel or no treatment. DESIGN Repeated measures design in which blood-flow and muscle-strength data were collected from ...

The behavior of tethered polymers on gel/gel adhesion is studied with the single-chain mean-field ~SCMF! theory. It is shown that the gel surface structure, the gel/gel adhesion strength, the equilibrium gel/gel distance, and the detailed interface structures can be tailored by specifically designed tethered layers on gel surfaces. The SCMF theory allows to study the effect of various variables...

An intracellular uricase from Bacillus fastidiosus with high catalytic capacity and strong resistance to xanthine was inactivated in water but could be essentially re-activated in solutions of high ionic strength. By polyacrylamide gel electrophoresis (PAGE), gradient PAGE, sodium-dodecyl-sulfate-PAGE, gel-filtration through Sephadex G200, and activity staining with peroxidase and its chromatog...

In this study, synthetic sulfonated polymers were used in order to enhance the rheological properties of drilling fluids. The capability of these polymers in reducing the effects of environmentally friendly, but harmful, pollutants such as cement, calcium chloride, gypsum as well as pH changes were investigated. In the present work, two sulfonated synthetic polymers, namely Polythin and Polydri...

Changes in the physicochemical properties of wheat, sago, tapioca and potato starches were studied after heating for 1 hour at 100oC, 110oC, and 120oC and for 2 hours at 120oC. These properties were characterised through the swelling behaviour of starch granules, amount of carbohydrate materials leached from the granules, starch paste retrogradation rate and gel strength. For all starches excep...