Freeze drying is one of the popular methods of fabrication for poly(lactide-co-glycolide) (PLGA) microspheres incorporated polymer scaffolds. However, the consequence of microspheres incorporation on physical and biological properties of scaffold has not been studied yet. In this study, attempt has been made to characterize the effect of PLGA microsphere incorporation on the physical properties...

OBJECTIVE To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). MATERIALS AND METHODS A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) re...

the effects of chitosan/biopolymer (c/p) and nanohydroxyapatite/ biopolymer (nha/p) weight ratios on particle size and its uniformity, cross-linking density and nh2 content of nano-hydroxyapatite/chitosan/gelatin (nha/c/g) microspheres were investigated. microspheres were fabricated using water-in-oil emulsion. cross-linking of microspheres was performed using water soluble carbodiimide. partic...

1961 B. Sree Giri Prasad* Teegala Krishna Reddy College of Pharmacy, Meerpet, Medbowli, Hyderabad, A.P, Email: [email protected] [email protected] Mobile No: 09441893479 Address for correspondence Oral modified-release multiple-unit dosage forms have always been more effective therapeutic alternative to conventional or immediate release single-unit dosage forms. With regar...

In the present study, gelatin microspheres containing ofloxacin were prepared by coacervation phase separation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and based on t...

Hydrogels are promising materials for bioengineering applications, and are good model materials for the study of hydrated biological tissues. As these materials often have a structural function, the measurement of their mechanical properties is of fundamental importance. In the present study gelatin gels reinforced with ceramic microspheres are produced and their poroviscoelastic response in sp...

Six polymerizable N,N'-diacylamides containing spatially arranged N-acryl, N-allyl and/or N-alkyl groups were prepared via two-step syntheses and characterized by 1H/13C NMR-spectra, refractive index (RI) and viscosity measurements. Photo DSC measurements on activated samples provided reactivity parameters ∆Hp, Rp,max and tmax, while FTIR spectra before and after curing elucidated the underlyin...

Freeze drying was compared with spray regarding feasibility to process wild thyme drugs in order obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration and heat-, ultrasound-, microwave-assisted extractions. Higher total powder yield (based on the weight prior extraction) achieved freeze than lower loss of polyphenol conten...