background and objectives: resistance in mycobacterium tuberculosis is caused by mutations in genes encoding drug targets. investigators have already demonstrated the existence of mutations in codons 88 to 94 in the gyra gene and also in codons 1400, 1401, and 1483 of rrs gene among extensively and extremely drug resistant tuberculosis (xdr & xxdr-tb) strains. the aim of this study was to ident...

AbstractIntroduction Rifampicin (RIF) is one of the most effective anti-tuberculosis first-line drugs prescribed along with isoniazid. However, emergence RIF resistance Mycobacterium tuberculosis (MTB) isolates a major issue towards tuberculosis (TB) control program in high MDR TB-burdened countries including Pakistan. Molecular data behind phenotypic essential for bett...

A nonsputum triage test to rule out tuberculosis (TB) disease is a WHO high-priority diagnostic, and combinatory score based on 3-gene host signature has shown promise in discriminating TB from other illnesses. We evaluated the accuracy of an early-prototype cartridge assay (“Xpert MTB Host Response” or Xpert-MTB-HR-Prototype) this biobanked blood samples people living with HIV (PLHIV) against ...

Recently, host whole blood gene expression signatures have been identified for diagnosis of tuberculosis (TB). Absolute quantification the concentrations signature transcripts in not reported, but would facilitate diagnostic test development. To identify minimal transcript signatures, we applied a selection procedure to microarray data from African adults comprising 536 patients with TB, other ...

In light of the marked global health impact of tuberculosis (TB), strong focus has been on identifying biosignatures. Gene expression profiles in blood cells identified so far are indicative of a persistent activation of the immune system and chronic inflammatory pathology in active TB. Definition of a biosignature with unique specificity for TB demands that identified profiles can differentiat...

the increasing incidence of multi drug resistance tuberculosis (mdr-tb) and extensively drug resistance tb (xdr-tb) worldwide highlight the urgent need to search for newer anti-tuberculosis compounds. it has been determined that pharmaceutical plant, hops ( humulus lupulus ), possesses some antibacterial effect. in this study, the antimycobacterial effect of this plant on rifampin sensitive and...

MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis was performed by including 22 studies (7095 TB-patients and 7662 controls) and d...

Backgrounds: There is a wide range of individual responses to mycobacterium infection. However, the reason why certain people suffers from disease when they are infected with while others remain healthy still unknown. Genetic susceptibility thought be one important explanatory factors for individuals risk developing pulmonary tuberculosis (TB). FokI polymorphism was genetic variations within vi...

Introduction. Multidrug resistance tuberculosis (MDR TB), the combined resistance of Mycobacterium tuberculosis to isoniazid (INH) and rifampin (RFM) is a major public health problem in India as it ranks second among the MDR-TB high burden countries worldwide. WHO recommends RFM resistance as a "surrogate marker" for detecting MDR. FNAC is the most widely used noninvasive investigative techniqu...

BACKGROUND Mannose-binding lectin (MBL) is an important protein in the lectin pathway of the immune system. This study explores the association between MBL polymorphism and the susceptibility to tuberculosis (TB). The association between the MBL2 polymorphisms and serum MBL levels is also analyzed in the present study. METHODS A total of 112 inpatients with pulmonary TB and 120 healthy contro...