Finnish variant LINCL (vLINCL(Fin)) is the result of mutations in the CLN5 gene. To gain insights into the pathological staging of this fatal pediatric disorder, we have undertaken a stereological analysis of the CNS of Cln5 deficient mice (Cln5-/-) at different stages of disease progression. Consistent with human vLINCL(Fin), these Cln5-/- mice displayed a relatively late onset regional atroph...

Epilepsy in Angelman Syndrome is thought to originate from an imbalance between local excitatory-inhibitory circuits that results in a generalized hyperexcitability. In this issue of Neuron, Judson et al. (2016) demonstrate that selective maternal deletion of Ube3a in cortical GABAergic neurons causes circuit hyperexcitability, increased seizure severity, and EEG abnormalities.

Crosstalk between neurons and glia may constitute a significant part of information processing in the brain. We present a novel method of statistically identifying interactions in a neuron-glia network. We attempted to identify neuron-glia interactions from neuronal and glial activities via maximum-a-posteriori (MAP)-based parameter estimation by developing a generalized linear model (GLM) of a...

given a mapping $f:xto x$ we naturally associate to it a monotonic map $gg_f:exp xto exp x$ from the power set of $x$ into itself, thus inducing a generalized topology on $x$. in this paper we investigate some properties of generalized topologies which are defined by such a procedure.

Many physiological events require an accurate timing signal, usually generated by neural networks called central pattern generators (CPGs). On the other hand, properties of neurons and neural networks (e.g. time constants of neurons and weights of network connections) alter with time, resulting in gradual changes in timing of such networks. Recently, a synaptic weight adjustment mechanism has b...

Noise cancellation in the field of Adaptive filtering has become the essential requirement of the signal processing .The standard multilayer perceptron (MLP) model of Neural Networks is now popular in Adaptive filtering This paper presents the noise-cancellation technique based on Generalized-mean neuron network (GMN). This network consists of an aggregation function, which is based on the gene...

Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders. Biomaterial scaffolds can improve cell differentiation and are widely used in translational medicine and tissue engineering. The aim...

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We study a family of non-linear McKean-Vlasov SDEs driven by Poisson measure, modelling the mean-field asymptotic network generalized Integrate-and-Fire neurons. give sufficient conditions to have periodic solutions through Hopf bifurcation. Our spectral involve location roots an explicit holomorphic function. The proof relies on two main ingredients. First, we introduce discrete time Markov Ch...