Integrating heterogeneous knowledge is necessary to elucidate the regulations in biological systems. In particular, such an integration is widely used to identify functional units, that are sets of genes that can be triggered by the same external stimuli, as biological stresses, and that are linked to similar responses of the system. Although several models and algorithms shown great success fo...

2012 will certainly be memorable as an Olympic year, but it has also seen a flurry of activity in the race to market biosimilar products. Keen to participate in this event, many countries throughout the world have established legal and regulatory pathways which allow manufacture of “copies” of a patent-expired biotherapeutic product. However, these are not simple generics as in the case of smal...

Understanding uncertainty in resource models is a significant requirement of ore deposit evaluation. Uncertainty analysis allows the modeller to explicitly quantify the risk around their estimate, along with provide high/low estimates for mine design, assess project up/down-side, model financial forecasts, and reconcile the deposit after mining. Geostatistical simulation is one method that can ...