Human developmental anatomy has been organized as structured lists of the major constituent tissues present during each of Carnegie stages 1-20 (E1-E50, approximately 8500 anatomically defined tissue items). For each of these stages, the tissues have been organized as a hierarchy in which an individual tissue is catalogued as part of a larger tissue. Such a formal representation of knowledge is...

Genomic sequencing efforts can implicate large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system to validate candidate gene association with pathology is therefore useful. We present such a system employing Drosophila to validate candidate congenital heart disease (CHD) genes. The protocols exploit comprehensive libraries of UAS-Gen...

Gene array studies can assess the global expression patterns of thousands of genes under multiple conditions. This technology can provide important insights about the underlying genetic causes of many important biological questions, and can change our understanding of diseases, ultimately allowing the development of novel chemical entities as potential drug candidates. The informatics analysis ...

Schematic Maps are mainly used for depicting transportation networks. They are generated through a schematization process where irrelevant details are eliminated and important details are emphasized. This process, being manually performed by teams of expert designers, is expensive and time consuming. Such manual execution is unsuitable for the production of schematic maps for location-based ser...

An optimal strategy based on minimum effort control and also with terminal positionconstraint is developed for an exoatmospheric interceptor with a fixed- interval guidance time. It isthen integrated with sliding-mode control theory to drive an optimal sliding-mode guidance law forfixed-interval guidance time. In addition, this guidance law is generalized for intercepting anarbitrarily time-var...