I organized this special theme issue to illustrate ways in which research in the physical and life sciences is stimulated by computational science, and conversely. The t it le—Crosstalk—is meant to epitomize such reciprocal exchanges. This magazine was originally created to facilitate this cross-fert i l izat ion, as was characterized by George Cybenko, CiSE ’s first editor in chief. In his int...

I will describe von Neumann’s elegant idea for sampling from the exponential distribution, Forsythe’s generalization for sampling from a probability distribution whose density has the form exp(−G(x)), where G(x) is easy to compute (e.g. a polynomial), and my refinement of these ideas to give an efficient algorithm for generating pseudo-random numbers with a normal distribution. Later developmen...

those without environmental insults or behavioural problems, as suggested in Drs Newell and Green's algorithm, diagnoses would have been missed. The three studies quoted were performed more than 10 years ago. Subsequent refinements in techniques of chromosome analysis allow identification of minor chromosome abnormalities that might previously not have been recognised-for example, in our series...

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trumpet of praise, and his enemies tried to give him a parting kick. We have nothing unkind to say of Sir George. True, lie once insulted the Calcutta doctors grievously by insinuating that they made false returns of their earnings. He was taken to book promptly and sharply on this account at the time. He was able to show that he was misled by statistics and made a frank and generous amende. Th...

George Klein, famous cancer biologist and acclaimed writer on matters of science, human responsibility, and the human condition, decorated by innumerable awards, honorary doctorates and other honors, elected member of this Academy and many other learned societies, including the Royal Swedish Academy of Sciences and the American Philosophical Society, and Member of the Nobel Assembly of Karolins...