BACKGROUND AND INTRODUCTION Gestational trophoblastic disease (GTD) is a disease of the proliferative trophoblastic allograft. Diagnosis and treatment of GTN in low resource-income countries is challenging due to numerous factors. The objective of this study was to review outcomes of gestational trophoblastic neoplasia in women of low socioeconomic status with limited resources and social suppo...

Gestational trophoblastic disease describes a number of gynaecological tumours that originate in the trophoblast layer, including hydatidiform mole (complete or partial), placental site trophoblastic tumour, choriocarcinoma and gestational trophoblastic neoplasia (GTN). Invasive moles are responsible for most cases of localized GTN. Two cases of GTN previously reported in the literature exhibit...

Trophoblastic neoplasms are a truly fascinating set of diseases that arise from a failed gestation. A molar pregnancy is an allograft of fetal tissue typically containing only paternal chromosomes that may invade the maternal decidua following a failed gestation that may have arisen up to decades earlier. Choriocarcinoma (CCA), the most common malignant form of trophoblastic disease, represente...

Extrauterine epithelioid trophoblastic tumors constitute an extremely rare gestational trophoblastic disease. We report the case of an extrauterine trophoblastic tumor that was incidentally detected in the left lung. Squamous cell carcinoma was suspected after microscopically examining the specimen obtained upon preoperative needle biopsy. After surgery, the tumor was confirmed by microscopic f...

In partial molar pregnancies, the trophoblast cells have three sets of chromosomes (triploid). Two sperm are believed to fertilise the ovum at the same time, leading to one set of maternal and two sets of paternal chromosomes. Around 10% of partial moles are tetraploid or mosaic in nature. There is usually evidence of fetal tissue or fetal blood cells in a partial molar pregnancy. An embryo may...

BACKGROUND Molar pregnancy represents a significant burden of disease on the spectrum of Gestational Trophoblastic Disease (GTD). The incidence appears to be quite high in South Asia. The objective of this study was to determine the frequency of GTD, and clinical presentation, management and outcome of patients with molar pregnancy. METHODS This retrospective, descriptive study was conducted ...

A placental site trophoblastic tumor requires care in management and a prompt diagnosis. Placental site trophoblastic tumor is a rare type of gestational trophoblastic disease and displays non-specific presentations similar to those of uterine arteriovenous malformation and those of non-neoplastic gestational trophoblastic diseases such as placental polypoid tumor. Diagnosis from biopsy is extr...

RATIONALE Gestational trophoblastic neoplasia is a group of rare tumors that can be cured using chemotherapy. The use of artificial contraception for at least 1 year is recommended not only due to the high recurrence rate in the first year after treatment, but also because of the unclear genetic toxic effects of multidrug regimen chemotherapy on reproductive cells. There is no consensus about t...

placental site trophoblastic tumor (pstt) is the rare variant of gestational trophoblastic diseases (gtd), which differs histologically and immunologically from gtd. diagnosis of pstt is often difficult and delayed. in most cases, diagnosis is not possible until the surgery is performed. the most therapeutic choice is hysterectomy and it is usually successful. here we report two cases of pstt.