preoperative gleason score (gs) obtained from trans rectal ultra sonography (trus) is the most common grading system to evaluate the appropriate treatment for patients with clinically localized prostate cancer. but this method showed upgraded and downgraded results in comparison to gleason score obtained from radical prostatectomy. the current study aimed to determine clinical or pathological v...

Since its initial description in 1966 by Dr Donald Gleason, Gleason grading has become the cornerstone in the management of prostate cancer (PCa). With widespread use of Prostate Specific Antigen (PSA) screening and needle core biopsy, the diagnosis and management of PCa have dramatically evolved. In addition, better understanding of the morphological spectrum of prostate cancer and its clinica...

INTRODUCTION Preoperative Gleason score is crucial, in combination with other preoperative parameters, in selecting the appropriate treatment for patients with clinically localized prostate cancer. The aim of the present study is to determine the clinical and pathological variables that can predict differences in Gleason score between biopsy and radical prostatectomy. METHODS We retrospective...

OBJECTIVES Prostate biopsy involvement and Gleason score guide treatment decisions in prostate cancer. We evaluated concordance in Gleason score and laterality between biopsy and radical retropubic prostatectomy (RRP) specimens and factors that influenced this relationship. MATERIALS AND METHODS We reviewed 538 prostate cancer diagnoses at a Veterans Affairs medical center (2000-2005) to iden...

THE 2005 AND 2014 MODIFIED GLEASON GRADING SYSTEMS One of the biggest changes to the Gleason grading system was the classification of Grades 1 and 2. Grade 1 tumors are generally benign, and Grade 2 tumors do not appear to differ from those classified as Grade 3. In 2005, Grade 2 was recommended to be used “rarely, if ever,” and in the 2014 modified Gleason grading system, grading started from ...

INTRODUCTION Based on the importance of the Gleason score on the behavior of prostate adenocarcinoma, this study attempts to predict the extension of prostate adenocarcinoma pre-operatively, as defined by the Gleason score on biopsy, in individuals who will undergo radical prostatectomy. MATERIALS AND METHODS We selected 899 individuals who underwent retropubic radical prostatectomy from 1988...

PURPOSE OF REVIEW The Gleason grading system provides important information for guiding prostate cancer patients' management and prognostication. The grading system underwent significant modifications over the past decade. In 2005 and more recently in 2014, the International Society of Urological Pathology (ISUP) held two consensus conferences to update prostate cancer grading. Recently, five p...

PURPOSE To evaluate if the expression of metalloproteinase, collagen I and III are related to Gleason score, preoperative PSA and pathological stage in prostate cancer. MATERIALS AND METHODS Our study group included radical prostatectomy specimens of 33 patients with prostatic adenocarcinoma who underwent surgery from 2001 to 2009. Patients were divided into 3 groups: Gleason score=6 (13 pati...

PURPOSE We determined the long-term clinical significance of primary Gleason pattern in patients with Gleason score 7 prostate cancer. MATERIALS AND METHODS We reviewed the records of all patients who underwent bilateral pelvic lymph node dissection and radical retropubic prostatectomy for Gleason score 7 prostate cancer at our institution. All patients who underwent adjuvant hormonal or radi...

Gleason score has long been considered the most powerful tissue-based predictor of outcome for prostate cancer. One of the strengths of this system is that it factors in the multiple grades that are often present in a single tumor. However, there is growing awareness of the limitations of Gleason grading. Specifically, few of the original Gleason criteria are currently used and cancers tend to ...