Neuropathology of a case of Shiga pedigree with proximal-dominant hereditary motor and sensory neuropathy (HMSN-P) is reported. In the spinal cord, marked atrophy of anterior and posterior roots was found. Histologically, severe neuronal loss and gliosis were evident in the spinal anterior horns. Bunina bodies and hyaline inclusions were not seen. Neuronal loss and gliosis were mild in the hypo...

a biopsy diagnosed patient with creut7,{eldt-jacob diseaseis reportedin. iran. this 53~year-old hunte'r,esented  n may 1994 to mehr hospital with typica clinical manifestations of creunfeldi-jacob disease and died 4 months later. brain biopsy revealed severe neuronal loss, spongiosis and gliosis oj cerebral cortex. e;xposureofthis hunter to the brain tissue ofanimals may explain the route of tr...

A patient presenting with the characteristic clinical features of Steele-Richardson-Olszewski syndrome is described, in whom neuropathological examination revealed atypical features, including extensive cortical and subcortical gliosis. The clinical and pathological features are discussed with particular reference to Creutzfeldt-Jacob disease and it is proposed that the case should be classifie...

Introduction The goal of this study was to identify MR spectroscopic (MRS) markers that are likely to be able to differentiate active tumor from treatment induced gliosis. This is an important problem because while tumor regions should be included in follow-up treatment plans, regions represented by gliosis should be left untouched since they represent areas of normal brain that are being influ...

Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive cells, which eventually form a bordering glial scar around the damaged area. Although reactive gliosis may protect the injured brain initially, the resulting glial scar i...

BACKGROUND Niemann-Pick disease Type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. The pathological mechanisms, underlying NPC1 are not yet completely understood. Especially the contribution of glial cells and gliosis to the progression of NPC1, are controversially discussed. As an analysis of affected cells is unfeasible in NPC1-patients, we r...

OF PATHOLOGICAL FINDINGS Striatun, Subst. nigra Red nucleus Cerebellum Case 1 Numerical Hassler (1939) reduction of small cells in caudate and putamen Case 2 Reduction of Hassler (1939) small cells. Small softenings in caudate and putamen Case 3 Fibrillar gliosis Mylle and van in pallidum Bogaert (1940) Case 4 Atrophy of Mylle and van putamen and Bogaert ( 1948) caudate-6tat cribl6, small softe...

Epidemiological studies have shown that an elevated uric acid (UA) level predicts the development of metabolic syndrome and diabetes; however, there is no direct evidence of this, and the underlying mechanism remains unclear. Here, we showed that a high-UA diet triggered the expression of pro-inflammatory cytokines, activated the NF-κB pathway, and increased gliosis in the hypothalamus. Intrace...