Filamin and Cortexillin are F-actin crosslinking proteins in Dictyostelium discoideum allowing actin filaments to form three-dimensional networks. GAPA, an IQGAP related protein, is required for cytokinesis and localizes to the cleavage furrow during cytokinesis. Here we describe a novel interaction with Filamin which is required for cytokinesis and regulation of the F-actin content. The intera...

A global o ensive alliance in a graph G = (V; E) is a subset S of V such that for every vertex v not in S at least half of the vertices in the closed neighborhood of v are in S. The cardinality of a minimum size global o ensive alliance in G is called the global o ensive alliance number of G. We give an upper bound on the global (strong) o ensive alliance number of a graph in terms of its degre...

For a graph G = (V,E), a non-empty set S ⊆ V is a global offensive alliance if for every v ∈ V − S, at least half of the vertices from the closed neighborhood of v are in S. A set S ⊆ V is a global strong offensive alliance if for each vertex v ∈ V −S, a strict majority of the vertices of the closed neighborhood of v are in S. The cardinality of a minimum global (strong) offensive alliance of a...

Science plays an increasingly important role in the development of international health policy and this has certainly been true in the case of a global response to alcohol-related problems. In May 2010, the World Health Assembly adopted resolution EB126.R11, Global strategy to reduce the harmful use of alcohol, 1 based in part on an impressive amount of evidence on both alcohol's contribution t...

Let G be a graph with vertex set V (G) and edge set E(G). A defensive alliance in G is a subset S of V (G) such that for every vertex v ∈ S, |N [v] ∩ S| ≥ |(V (G)−N [v]) ∩ S|. A global defensive alliance is an alliance that is also a dominating set. We define the alliance partition number, ψa(G) (global alliance partition number, ψg(G)), to be the maximum number of sets in a partition of V (G) ...

Comparison of the phenotypic expression of Mycoplasma gallisepticum strain R low (passage 15) to that of strain R high (passage 164) revealed that three proteins, i.e., the cytadhesin molecule GapA, a 116-kDa protein (p116), and a 45-kDa protein (p45), are missing in strain R high. Sequence analysis confirmed that the insertion of an adenine 105 bp downstream of the gapA translational start cod...

Chloroplast glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is composed of two different subunits, GAPA and GAPB, which are encoded in the nucleus by two related genes of eubacterial origin. In the present work the genes encoding chloroplast GAPA and GAPB from pea have been cloned and sequenced. The gene for GAPB is split by eight introns. Two introns interrupt the region encoding the transit ...

It gives me great pleasure to participate in the launch of this inaugural issue of Global Mental Health as an Associate Editor for Policy and Systems. In my capacity as the Executive Director of the Alliance for Health Policy and Systems Research at WHO, I have been privileged to witness the expansion of Health Policy and Systems Research and its increasing relevance and impact in other fields,...

Little research has been done on the role of the therapeutic working alliance in treatment for alcohol problems. This longitudinal study's objectives were (a) to identify predictors of working alliance and (b) to investigate whether client and/or therapist reports of the working alliance predicted posttreatment motivation and then later treatment outcome. Client and therapist perceptions of the...