Utilizing the fluorescent antibody method for the histologic demonstration of localized gamma-globulins, we have made the following observations (in contradistinction to the lack of such findings in a variety of normal and pathologic, control kidneys). In systemic lupus erythematosus (a) gamma-globulins were localized in the thickened capillary walls, the "wire-loop" lesions, and the so called ...

The electrophoretic fractions of serum proteins were studied up to the 5th generation in a colony of germ-free rats. The germ-free animals had significantly lower concentrations of beta and the gamma globulins, while the other fractions were within normal limits. Assuming that the gamma globulins survive equally long in the circulation in germ-free animals as in controls, the production of gamm...

Aberrations of protein metabolism in multiple myeloma have been studied by a number of investigators (1-6) to ascertain whether the globulins in the blood consist of excesses of normal globulins or of chemically abnormal globulins, or both. Such research has been directed toward determining whether "characteristic protein abnormalities" could be distinguished by 1) separation of the serum prote...

Gm types of sera from Caucasians and Negroes, of myeloma globulins, and of specific antibodies were investigated. In particular the relationship between the recently identified gene Gm(f) and other Gm genes was analyzed. 1. Caucasians were, with rare exceptions, either Gm(b+f+) or Gm(b-f-). 2. In Negroes, on the other band, type Gm(b+f-) was found to be common. 3. No myeloma globulins appeared ...

BACKGROUND The recent epidemic of diabetes mellitus (DM) in Africa, coupled with rampant poverty, is an indication of the urgent need to develop new efficacious, cheaper and more available drugs to face this growing public health challenge. A number of plants products among which the protein-rich Cucurbitaceae seeds are commonly used in traditional medicine with increasing acclaimed efficacy ag...

The aim of the study was to determine the changes in the content of major proteins, glucose and selected hormones in the blood of piglets during the first 7 days of neonatal life. The study involved an entire litter of eight newborn piglets of F1 hybrids (Polish White Large x Polish Landrace) delivered from one sow in the second gestation. In blood samples collected directly after parturition (...

The opsonic properties of immune gammaG-globulins isolated from patients with chronic septicemic conditions, principally subacute bacterial endocarditis were studied. Opsonic capacity as well as complement-fixing properties of gamma-globulins appeared to be closely associated with integrity of Fc structures. Progressive pepsin digestion of immune gammaG-globulins, as monitored by successive los...

While working with the urease of the jack bean, the author has had occasion to study the nature of the proteins that are present. The proteins of the jack bean have been investigated by Jones and Johns,’ who claim to have isolated an albumin and two globulins. The precipitate obtained by half saturation with ammonium sulfate, present in small amount and having the greater sulfur content, they c...

distilled water it becomes cloudy owing to partial precipitation of the serum globulin. Under certain circumstances, a copious precipitate forms instead of a mere cloudiness. This precipitate is due to a globulin-like substance as is evident from the following facts:? (1) It is soluble in normal saline, in dilute acids, and in dilute soda bicarb, solution. It is also soluble in sodium hydrate s...

210 Blood, Vol. 39, No. 2 (February), 1972 Blood obtained from seven patients with lambda type myeloma proteins showed evidence of gelatinous bulky clots, impaired clot retraction, and circulating anticoagulant activity associated with interference of fibrin monomer polymerization. Five patients had G1 and two had A1 myeloma proteins. The pathologic plasmas and isolated myeloma proteins had ant...