INTRODUCTION Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients. The human GLS gene promoter contains at least seven consensus binding sites for the DNA binding protein Sp1. Here we examined whether Sp1 is necessary for GLS production in RA. ...

Generalized least squares (GLS) for model parameter estimation has a long and successful history dating to its development by Gauss in 1795. Alternatives can outperform GLS in some settings, and alternatives to GLS are sometimes sought when GLS exhibits curious behavior, such as in Peelle’s Pertinent Puzzle (PPP). PPP was described in 1987 in the context of estimating fundamental parameters tha...

Guided Local Search (GLS) is a general meta-heuristic that sits on top of local search algorithms and help them escape from local minima. However, GLS is often trapped in a small local area. Estimation of Distribution Algorithm(EDA) is a new evolutionary algorithm in which statistical information are explicitly extracted from the current population and then used for generating new solutions. Th...

Granular lymphocytes (GLs) in patients with GL-proliferative disorders (GLPDs) are known to express the interleukin-2 receptor (IL-2R) p chain (p70-75) constitutively and to proliferate in response to stimulation with IL-2 via the p chain. In this report, we found that the anti-CD3 monoclonal antibody (MoAb) OKT3 could induce the proliferation of GLs from patients with T-cell lineage GLPDs (T-c...

Constraint satisfaction and optimisation is NP-complete by nature. The combinatorial explosion problem prevents complete constraint programming methods from solving many real-life constraint problems. In many situations, stochastic search methods, many of which sacrifice completeness for efficiency, are needed. This paper reports a family of stochastic algorithms for constraint satisfaction and...

This paper introduces ILS Miner, a novel method for discovering process models from event logs using iterated local search. A comparison between ILS Miner, GLS Miner and HeuristicMiner is presented in this paper. GLS Miner was chosen because applies Guided Local Search for discovering process models from event logs, HeuristicMiner[10] being a legacy method in business process discovery. It is s...

AIMS Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-co...

AIMS While abnormal resting LV GLS has been described in patients with chronic heart failure with preserved ejection fraction (HFpEF), its prognostic significance when measured during an acute heart failure hospitalization remains unclear. We assessed the association between left ventricular global longitudinal strain (LV GLS) and outcomes in patients hospitalized with acute HFpEF. METHODS AN...

We propose a framework for joint entropy coding and encryption using Chaotic maps. We begin by observing that the message symbols can be treated as the symbolic sequence of a discrete dynamical system. For an appropriate choice of the dynamical system, we could back-iterate and encode the message as the initial condition of the dynamical system. We show that such an encoding achieves Shannon’s ...

The Grid Location Service (GLS) is a location service which provides location information for a node in a mobile ad hoc network. GLS provides a mechanism for a node to track the location of other nodes in the network topology. A mobile ad hoc network (MANET) is an autonomous system of mobile routers (and associated hosts) connected by wireless links–the union of which form an arbitrary graph. T...