background: pentavalent antimonials are the first line drugs for the treatment of leishmaniasis. unresponsiveness of leishmania spp. to antimonial drugs is a serious problem in some endemic areas. investigations on molecular mechanisms involved in drug resistance are essential for monitoring and managing of the disease. cal-cineurin is an essential protein phosphatase for number of signal trans...

Pentamidine was compared with meglumine antimoniate (Glucantime) for 80 patients with cutaneous leishmaniasis due to Leishmania braziliensis in Peru. Of the 40 patients administered Glucantime (20 mg of antimony [Sb]/kg/day intravenously for 20 days), 31 cured (78%), 6 failed (15%), of which 5 were due to relapse, and 3 were lost to follow-up (7%). Of the 40 patients administered pentamidine (2...

Toxicity and drug resistance against pentavalent antimonials, medications of choice in treatment of leishmaniasis for more than 5 decades, have become important subjects globally. This study was a randomized, open labeled trial that was designed to determine efficacy and safety of IMOD as a novel herbal immunomodulator drug for treatment of canine visceral leishmaniasis (CVL). Twenty healthy mo...

background: this study was designed to detect whether there is a correlation between in vitro susceptibility of field isolates of leishmania major and the clinical outcomes of meglumine antimoniate (glucantime®) therapy, the main­stay of cutaneous leishmaniasis treatment in iran. methods: forty-three patients infected with l. major were enrolled in this study from october 2009 to march 2010 and...

BACKGROUND & OBJECTIVES Leishmaniasis is a parasitic disease transmitted by sand flies. Many investigations are performed to find an effective and safe treatment for leishmaniasis. In this study, we evaluated the efficacy of herbal extracts of Thymus vulgaris (Thyme) and Achillea millefolium (Yarrow), propolis hydroalcoholic extract and systemic glucantime against cutaneous leishmaniasis in Bal...

PURPOSE The labeling of red blood cells (C) with 99mTc is employed in clinical nuclear medicine for a variety of diagnostic procedures. Drugs can alter this labeling method and modify the disposition of the radiopharmaceuticals. In this paper, the influence of glucantime on the labeling of blood constituents with 9mTc was reported. METHODS Blood was withdrawn from rats and incubated with gluc...

Objetivo: evaluar la eficacia clínica de aplicación intralesional 3 versus, 6 inyecciones Glucantime®, durante una o dos semanas en pacientes con leishmaniasis cutánea.
 Métodos: estudio tipo cuasi experimental. Se incluyó a 41 cutánea del área endémica tropical Cochabamba, Bolivia. Los pacientes, fueron distribuidos aleatoriamente para recibir tratamiento tres seis aplicaciones. Todos ell...

BACKGROUND In this study, two-dimensional gel electrophoresis (2-DE) method was applied to determine and compare the protein spots expressed in the two field isolates of Leishmania major and recovered from the patients who were clinically sensitive and resistant to Glucantime® treatment. METHODS Leishmania parasites were isolated from the cutaneous lesions of two CL infected patients in Shira...