This paper describes a wireless, remote query glucose biosensor using a ribbonlike, mass-sensitive magnetoelastic sensor as the transducer. The glucose biosensor is fabricated by first coating the magnetoelastic sensor with a pH-sensitive polymer and upon it a layer of glucose oxidase (GOx). The pH-responsive polymer swells or shrinks, thereby changing mass, respectively, in response to increas...

This paper presents a noninvasive wireless sensor platform for continuous health monitoring. The sensor system integrates a loop antenna, wireless sensor interface chip, and glucose sensor on a polymer substrate. The IC consists of power management, readout circuitry, wireless communication interface, LED driver, and energy storage capacitors in a 0.36-mm CMOS chip with no external components. ...

BACKGROUND Subcutaneously-implanted glucose sensors for continuous glucose monitoring have the potential to replace serial blood glucose measurements. The objective of the present study was to test whether continuous glucose measurements could be obtained with glucose sensors implanted in the subcutis of pigs. Moreover, the in vivo biocompatibility of the sensors was evaluated since an inflamma...

Some people suffering from diabetes use insulin injection pumps to control the blood glucose level. Sometimes, the fault may occur in the sensor or actuator of these pumps. The main objective of this paper is controlling the blood glucose level at the desired level and fault-tolerant control of these injection pumps. To this end, the eligibility traces algorithm is combined with the sliding mod...

A new glucose sensor based on field emitter of ZnO nanorod arrays (ZNA) was fabricated. This new type of ZNA field emitter-based sensor shows high sensitivity with experimental limit of detection of 1 nM glucose solution and a detection range from 1 nM to 50 μM in air at room temperature, which is lower than that of glucose sensors based on surface plasmon resonance spectroscopy, fluorescence s...

The development of an electrochemically based implantable sensor for glucose is described. The sensor is needle-shaped, about the size of a 28-gauge needle. It is flexible and must be implanted subcutaneously by using a 21-gauge catheter, which is then removed. When combined with a monitoring unit, this device, based on the glucose oxidase-catalyzed oxidation of glucose, reliably monitors gluco...

Here, efforts toward the development of a microneedle-based glucose sensor or "smart patch" for intradermal glucose sensing are described. Metallic microneedle array electrodes, conducting polymers, and glucose oxidase form the sensor platform. This work represents the first steps toward the development of painless, transdermal-sensing devices for continuous glucose monitoring.

A new electron-transfer mediator, 5-[2,5-di (thiophen-2-yl)-1H-pyrrol-1-yl]-1,10-phenanthroline iron(III) chloride (FePhenTPy) oriented to the nicotinamide adenine dinucleotide-dependent-glucose dehydrogenase (NAD-GDH) system was synthesized through a Paal-Knorr condensation reaction. The structure of the mediator was confirmed by Fourier-transform infrared spectroscopy, proton and carbon nucle...

OBSTRUCTIVE SLEEP APNEA SYNDROME (OSAS) HAS BEEN REPEATEDLY SHOWN TO BE ASSOCIATED WITH IMPAIRED GLUCOSE METABOLISM, RESULTING MAINLY FROM INSULIN RESISTANCE,1-3 and, more recently, OSAS has been linked to the metabolic syndrome.4 However, data on early or late effects of OSAS treatment with continuous positive airway pressure (CPAP) on blood glucose and insulin resistance are conflicting.5-9 W...

BACKGROUND This study evaluated the accuracy and performance of a fourth-generation subcutaneous glucose sensor (Guardian™ Sensor 3) in the abdomen and arm. METHODS Eighty-eight subjects (14-75 years of age, mean ± standard deviation [SD] of 42.0 ± 19.1 years) with type 1 or type 2 diabetes participated in the study. Subjects wore two sensors in the abdomen that were paired with either a Mini...