conclusions the findings confirmed the positive influence of ud supplements and aerobic training on glycemic control in males with t2dm. when aerobic training was combined with a ud supplement, a greater degree of glycemic control was observed. results a significant decrease in fasting blood sugar (fbs) was observed in the ae group (-9.50 ± 6.96 mg/dl; p = 0.002), the ud group (-7.60 ± 6.04 mg/...

Diabetes is the most common cause of CKD (chronic kidney disease). also one important diabetic complication. SGLT2 (sodium glucose co‐transporter‐2) inhibitors are new class medication used to lower high blood level in people with type 2 diabetes. In researches demonstrated a significant and clinically relevant reduction risks albuminuria progression nephropathy, doubling serum creatinine level...

We report the onset of euglycemic diabetic ketoacidosis (EDKA) in a 20-year-old male patient with new-onset type 2 diabetes mellitus (T2DM) 5 days after initiation diet restriction and combination SGLT2 (sodium–glucose co-transporter 2) inhibitors, glucagon-like peptide 1 receptor agonists, metformin. The use inhibitors symptomatic patients T2DM along extreme reduction carbohydrate intake might...

The intracellular C-terminal domain is diverse in size and amino acid sequence among facilitative glucose transporter isoforms. The characteristics of glucose transport are also divergent, and GLUT2 has far higher Km and Vmax values compared with GLUT1. To investigate the role of the intracellular C-terminal domain in glucose transport, we expressed in Chinese hamster ovary cells the mutated GL...

In diabetes, both activation of renin-angiotensin system and glomerular hyperfiltration are seen even before the development of diabetic nephropathy. Glomerular hyperfiltration depends on glomerular hypertension sue to pathophysiological afferent arteriolar dilation. Tubular hypothesis has been proposed more than a decade ago to explain the above in type1 diabetes. Recently, clinical evidences ...

D-Glucose deprivation of primary rat brain glial cell cultures, by incubation with 25 mM D-fructose for 24 h, resulted in a 4-5-fold induction of D-glucose transport activity. In contrast, 24-h D-glucose starvation of primary rat brain neuronal cultures had only a marginal effect (1.5-2-fold) on D-glucose transport activity. Northern blot analysis of total cellular RNA demonstrated that under t...

Objective(s): The aim of this study was to explore the molecular mechanism of mirtazapine with respect to energy metabolism in Streptozotocin-induced diabetic liver of rats by immunohistochemistry and Western blot. Materials and Methods: Twenty-one male Sprague-Dawley rats were assigned into 3 groups including control, type 1 diabetes me...