Abstract Background Gamma-aminobutyric acid (GABA) is an important bio-product used in pharmaceuticals and functional foods as a precursor of the biodegradable plastic polyamide 4. Glutamate decarboxylase (GAD) converts l -glutamate ( -Glu) into GABA via decarboxylation. Compared with other methods, develop bioconversion platform to produce considerable interest for industrial use. Results Thre...

background: obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. glutamate decarboxylase 2 (gad2) gene is associated with obesity and it regulate food intake and insulin level. we investigated the association of gad-2gene −243a>g (rs2236418) and +61450c>a (rs992990) polymorphisms with obesity and related phenotypes. methods: insulin, glucose and lipid lev...

There is ample experimental evidence which indicates that 4-aminobutyric acid is an inhibitory neurotransmitter in mammalian brain. Changes in 4-aminobutyric acid concentrations in the central nervous system have therefore prompted speculation regarding its involvement in neurological aberrations. Individuals homozygous for cystathionine /3-synthase deficiency (an autosomal recessive inherited ...

–Dopaminergic axons arising from midbrain nuclei innervate the mammalian and avian telencephalon with heterogeneous regional and laminar distributions. In primate, rodent, and avian species, the neuromodulator dopamine is low or almost absent in most primary sensory areas and is most abundant in the striatal parts of the basal ganglia. Furthermore, dopaminergic fibres are present in most limbic...

Acid resistance (AR) in Escherichia coli is defined as the ability to withstand an acid challenge of pH 2.5 or less and is a trait generally restricted to stationary-phase cells. Earlier reports described three AR systems in E. coli. In the present study, the genetics and control of these three systems have been more clearly defined. Expression of the first AR system (designated the oxidative o...