In enterocytes, glutamine serves as the major source of energy; another metabolic fate of glutamine is conversion to citrulline. Because sepsis can affect gut function and integrity, alterations in glutamine metabolism may exist and lead to decreased citrulline production. This study aimed to investigate how sepsis affects glutamine metabolism, including its conversion to citrulline, by measuri...

Amino acid dehydrogenases (L-amino acid: oxidoreductase deaminating EC 1.4.1.X) are members of the wider superfamily of oxidoreductases that catalyze the reversible oxidative deamination of an amino acid to its keto acid and ammonia with the concomitant reduction of either NAD+, NADP+ or FAD. These enzymes have been received much attention as biocatalysts for use in biosensors or diagnostic kit...

Glutamine transport between tissues is important for the outcome of critically ill patients. Investigation of glutamine kinetics is, therefore, necessary to understand glutamine metabolism in these patients in order to improve future intervention studies. Endogenous glutamine production can be measured by continuous infusion of a glutamine tracer, which necessitates a minimum measurement time p...

objective(s): the purpose of the present study was to examine the effects of l-glutamine on electromyographic (emg) activity of the quadriceps muscle injured by eccentric exercise (ee).   materials and methods: seventeen healthy men (age: 22.35±2.27 yr; body mass: 69.91±9.78 kg; height: 177.08±4.32 cm) were randomly and double-blind study with subjects assigned to either an l-glutamine suppleme...

Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements. While many cancer cells depend on exogenous glutamine for survival to justify the therapeutic targeting of glutamine metabolism, the mechanisms of glutamine dependence and likely res...

mgm. per cent 0 0 0 0 0 0 ++++ Filtered yeast extract (1/100)............ ++++ ++++ ++++ ++++ ++++ ++++ Autoclaved yeast extract (1/100) .0 0 0 0 0 ++++ Glutamine (filtered) ..001 0 0 0 0 0 ++++ Glutamine (filtered) ....... .01 0t 4 O ++++ Glutamine (filtered)....... .1 ++ ++ ++ + + ++++ Glutamine (filtered)....... 1 ++++++++++++ ++++++++++ Glutamine (filtered)....... 10 ++++ ++++ ++++ ++++++++...

CONTENTS INTRODUCTION . . 4 4 EVIDENCE FOR G U T MUCOSAL BARRIER DYSFUNCTION . . 4 4 CLINICAL SIGNIFICANCE OF G U T MUCOSAL BARRIER DYSFUNCTION . . 46 GUT DERIVED SEPSIS: THERAPEUTIC STRATEGIES. . . 41 NOVEL SUBSTRATES A N D G U T INTEGRITY . . 48 GLUTAMINE . . 48 Metabolism of glutamine . . 48 Glutamine and the gut mucosa . . 48 Glutamine and experimental disease models . . * 49 Glutamine supp...

1. During infusion of [5-15N]glutamine in patients with gastrointestinal cancer we unexpectedly observed a gradual decrease in time of the appearance rate (Ra) of glutamine in plasma. Here we investigate whether the failure to achieve a plateau isotopic enrichment in plasma is, among other factors, due to incomplete equilibration of the glutamine tracer with the large intramuscular free glutami...