glutathione transferase (gst) is a family of multifunctional detoxification enzymes which are mainly cytosolic that detoxify natural and exogenous toxic compounds through conjugation with glutathione tripeptide. its conjugates can be transported to vacuoles or apoplast. these conjugates are generally less toxic than the parent compounds. glutathione transferase is identified and isolated from m...

results the level of gsh significantly decreased. in contrast, the plasma level of mda significantly increased in a dose dependent manner in crvi-treated rats, when compared to control animals. simv had no effect on the biochemical parameters when compared to control rats, but significantly increased gsh concentration and decreased mda level in crvi-treated rats. materials and methods sixty-fou...

glutathione s-transferases (gsts) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. the human gsts are divided into four classes: alpha, mu, pi and theta. previous studies indicated that the absence of the glutathione s-transferase m1 (gstm1) protein correlated with an increased risk of developing some types of cancers. association between spe...

background: dzn (diazinon) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. the aim of present study was to evaluate the effects of dzn on mda (malondialdehyde) and gsh (glutathione) levels in female rat reproductive tissue (ovary) and to a...

background: in fertile women, glycodelin and glutathione peroxidase 3 (gpx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. the expression of these genes decreases in women with myomas. to determine whether myomectomy would reverse glycodelin and gpx3 expression, we evaluated the transcript levels of these genes in the endometrium of patien...

background: neuropathic pain (np) is a serious suffering medical condition that frequently leads to disability and life style changes. although the exact mechanisms of np are still unknown, recently the role of reactive oxygen species (ros) reported as an important factor for np. apoptosis, increase of atp production and reduction of antioxidants are also the other factors influencing in np. th...

conclusions it is concluded one week oral supplementation of curcumin has positive effects on selected indices of oxidative stress possibly via promotion of antioxidant capacity. results there was a significant increase in tac after supplementation (p < 0.001, es = 1. 42), and immediately after exercise (p = 0. 008, es = 1. 12) in c group compared with the p group. mda-tbars was significantly l...

the electrochemical oxidation and determination of tryptophan (trp) and glutathione (gsh) in the presence of catechol as a homogeneous redox in the aqueous medium were investigated at the surface of a carbon paste electrode modified with multi-walled carbon nanotube (mwcnt-cpe) using cyclic voltammetry (cv), double step potential chronoamperometry and differential pulse voltammetry (dpv) techni...