Serum levels of glutathione reductase (GR), glutathione S-transferase-alpha (GST-alpha) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-alpha and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3...

Altered antioxidant status has been reported in schizophrenia. The glutathione (GSH) redox system is important for reducing oxidative stress. GSH, a radical scavenger, is converted to oxidized glutathione (GSSG) through glutathione peroxidase (GPx), and converted back to GSH by glutathione reductase (GR). Measurements of GSH, GSSG and its related enzymatic reactions are thus important for evalu...

Submit Manuscript | http://medcraveonline.com J Aquac Mar Biol 2015, 2(4): 00035 Abbreviations: SOD: Superoxide Dismutase; CAT: Catalase; TAC: Total Antioxidant Capacity; MDA: Malondialdehyde; ROO: Primarily Peroxyl Radicals; GPX: Glutathione Peroxidase; ROS: Reactive Oxygen Species; GST: Glutathione-S-Transferase; GR: Glutathione Reductase; PPT: Parts Per Trillion; Ppm: Parts Per Million; RPM:...

Cadmium (Cd) is one of the most toxic heavy metals in plants. To investigate whether Cd induces common plant defense pathways, different physiological and molecular reactions, including modifications in glutathione (GSH) level, activity and gene expression of glutathione reductase (GR) enzyme were characterized in roots of hydroponically cultivated-Vicia seedlings during 12, 24 and 48 h. Vicia ...

Heavy metals are the cause of major abiotic stresses in plants and a principal contributor to environmental pollution in recent decades. This study investigated the effects of exogenous hydrogen sulfide on the ascorbate-glutathione cycle in the leaves of coriander seedlings under copper stress. Results showed that copper stress not only reduced APX and GR activities but also decreased leaf AsA,...

OBJECTIVE Thiol oxidative stress leads to macrophage dysfunction and cell injury, and has been implicated in the development of atherosclerotic lesions. We investigated if strengthening the glutathione-dependent antioxidant system in macrophages by overexpressing glutathione reductase (GR) decreases the severity of atherosclerosis. METHODS AND RESULTS Bone marrow cells infected with retrovira...

External applications of strigolactones affect plant growth positively owing to the potential adapting plants tolerance system under stress conditions. In this study, effect synthetic analogue strigolactone (GR24) pre-treatment seeds salt-tolerant and salt-sensitive bread wheat (Triticum aestivum L.) varieties on parameters, antioxidant enzymes, such as superoxide dismutase (SOD), ascorbate per...

Inflammation plays an essential role in arthritis development and progression. Despite the advances pharmaceutical field, current treatments still present low efficacy severe side effects. Considering high activity of glutathione reductase (GR) enzyme inflamed joints, a distinctive drug delivery system sensitive to GR was designed for efficient on arthritic diseases. A linear amphiphilic polyme...

BACKGROUND Xenobiotics are neurotoxins that dramatically alter the health of the child. In addition, an inefficient detoxification system leads to oxidative stress, gut dysbiosis, and immune dysfunction. The consensus among physicians who treat autism with a biomedical approach is that those on the spectrum are burdened with oxidative stress and immune problems. In a trial to understand the rol...

the present study investigates the antioxidant potential of the ethyl acetate fraction of the aerial parts eclipta alba l. hassk (eaea) which was widely used as hepatoprotective plant. eaea was orally administered at doses of 50, 100 and 200 mg/kg for 7 days in male charles foster rats. the extent of hepatoprotective potential of e . alba was studied by assessing the biochemical parameters like...